Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(2-Pyridyldithio)-PEG1-hydrazine is a one-unit cleavable polyethylene glycol (PEG) linker specifically designed for the synthesis of antibody-drug conjugates (ADCs). This linker offers the advantage of controlled release of the drug payload from the ADC construct. It is utilized in the conjugation process between the antibody and the cytotoxic drug, enabling the targeted delivery of the drug to cancer cells. The (2-pyridyldithio) group of this linker provides stability during circulation in the bloodstream, while the hydrazine moiety allows for efficient drug release at the tumor site. Overall, the (2-pyridyldithio)-PEG1-hydrazine linker serves as a valuable tool in the development of targeted chemotherapeutic agents for cancer treatment.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 mg | 5 days | Inquiry | |
500 mg | 5 days | Inquiry |
Description | (2-Pyridyldithio)-PEG1-hydrazine is a one-unit cleavable polyethylene glycol (PEG) linker specifically designed for the synthesis of antibody-drug conjugates (ADCs). This linker offers the advantage of controlled release of the drug payload from the ADC construct. It is utilized in the conjugation process between the antibody and the cytotoxic drug, enabling the targeted delivery of the drug to cancer cells. The (2-pyridyldithio) group of this linker provides stability during circulation in the bloodstream, while the hydrazine moiety allows for efficient drug release at the tumor site. Overall, the (2-pyridyldithio)-PEG1-hydrazine linker serves as a valuable tool in the development of targeted chemotherapeutic agents for cancer treatment. |
In vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. |
Synonyms | (2-pyridyldithio)-PEG1-hydrazine |
Molecular Weight | 187.28 |
Formula | C7H9NOS2 |
CAS No. | 111625-28-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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(2-pyridyldithio)-PEG1-hydrazine 111625-28-6 (2pyridyldithio)PEG1hydrazine (2 pyridyldithio) PEG1 hydrazine (2-pyridyldithio)-PEG-1-hydrazine inhibitor inhibit