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Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine

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Catalog No. T17165Cas No. 175724-30-8
Alias tris-2-tert-butoxycarbonyl-ethoxy-methyl-methylamine

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine, a cleavable PEG ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs). It is also a PEG-based PROTAC linker, specifically Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane, widely used in the synthesis of PROTACs [1].

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine

😃Good
Catalog No. T17165Alias tris-2-tert-butoxycarbonyl-ethoxy-methyl-methylamineCas No. 175724-30-8
Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine, a cleavable PEG ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs). It is also a PEG-based PROTAC linker, specifically Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane, widely used in the synthesis of PROTACs [1].
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Bioactivity
Description
Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine, a cleavable PEG ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs). It is also a PEG-based PROTAC linker, specifically Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane, widely used in the synthesis of PROTACs [1].
In vitro
ADCs consist of an antibody linked to an ADC cytotoxin via an ADC linker[1]. PROTACs feature two ligands connected by a linker; one targets an E3 ubiquitin ligase, the other targets the protein of interest. PROTACs utilize the intracellular ubiquitin-proteasome system for selective protein degradation[1].
Synonymstris-2-tert-butoxycarbonyl-ethoxy-methyl-methylamine
Chemical Properties
Molecular Weight505.64
FormulaC25H47NO9
Cas No.175724-30-8
Relative Density.1.065 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Keywords

Tris[[2(tertbutoxycarbonyl)ethoxy]methyl]methylamineTris[[2 (tert butoxycarbonyl)ethoxy]methyl]methylaminePEGsCleavableADCLinkerADC Linker
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