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VRK-IN-1

🥰Excellent
Catalog No. T35863Cas No. 2378855-09-3

VRK-IN-1 is a potent and selective inhibitor of [cowpox-associated kinase 1 (VRK1)], suitable for researching neurological disorders.

VRK-IN-1

VRK-IN-1

🥰Excellent
Purity: 99.25%
Catalog No. T35863Cas No. 2378855-09-3
VRK-IN-1 is a potent and selective inhibitor of [cowpox-associated kinase 1 (VRK1)], suitable for researching neurological disorders.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$105In StockIn Stock
5 mg$249In StockIn Stock
10 mg$398In StockIn Stock
25 mg$789In StockIn Stock
50 mg$1,190In StockIn Stock
100 mg$1,590-In Stock
200 mg$2,170-In Stock
1 mL x 10 mM (in DMSO)$273In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.25%
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COA LCMS

Product Introduction

Bioactivity
Description
VRK-IN-1 is a potent and selective inhibitor of [cowpox-associated kinase 1 (VRK1)], suitable for researching neurological disorders.
Targets&IC50
VRK1:150 nM (IC50), VRK1:150 nM
In vitro
VRK-IN-1 (3.2 μM; 24 hours) slightly decreases the viability of human HeLa cells[1].
Chemical Properties
Molecular Weight349.28
FormulaC18H11F4NO2
Cas No.2378855-09-3
SmilesCc1ncc(cc1-c1cc(F)c(O)c(F)c1)-c1cc(F)c(O)c(F)c1
Relative Density.1.436 g/cm3 (Predicted)
ColorYellow
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (229.04 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8630 mL14.3152 mL28.6303 mL143.1516 mL
5 mM0.5726 mL2.8630 mL5.7261 mL28.6303 mL
10 mM0.2863 mL1.4315 mL2.8630 mL14.3152 mL
20 mM0.1432 mL0.7158 mL1.4315 mL7.1576 mL
50 mM0.0573 mL0.2863 mL0.5726 mL2.8630 mL
100 mM0.0286 mL0.1432 mL0.2863 mL1.4315 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

VRK-IN-1VRKIN1VRK IN 1
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