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SC57666

Name: SC57666
Brand: TargetMol
SKU: T12860
Price: 118 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12860Cas No. 158959-32-1

SC57666 is a highly selective COX2 inhibitor (IC50 at 26 nM) that shows no activity against COX1.

SC57666

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Purity: 98.83%

Catalog No. T12860Cas No. 158959-32-1

SC57666 is a highly selective COX2 inhibitor (IC50 at 26 nM) that shows no activity against COX1.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$118	In Stock	In Stock
5 mg	$257	In Stock	In Stock
10 mg	$412	In Stock	In Stock
25 mg	$702	In Stock	In Stock
50 mg	$918	In Stock	In Stock
100 mg	$1,190	In Stock	In Stock
200 mg	$1,590	-	In Stock
1 mL x 10 mM (in DMSO)	$283	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.83%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR FNMR

Product Introduction

Bioactivity

Description	SC57666 is a highly selective COX2 inhibitor (IC50 at 26 nM) that shows no activity against COX1.
Targets&IC50	COX-2:26 nM
In vitro	SC57666 exhibits potent inhibition of COX2 (IC50 of 3.2±0.8 nM) in CHO cells stably transfected with human COX isozymes, showing a selectivity of 1000-fold or greater over COX1 (IC50=6000±1900 nM) [1].
In vivo	In the adjuvant-induced arthritis model, SC57666 exhibits oral activity with an ED50 of 1.7 mpk. When administered orally at a dose of 600 mpk, SC57666 does not cause gastric lesions in mice after 5 hours. Similarly, no intestinal damage is observed in rats after 72 hours when administered orally at a dose of 200 mpk [2].

Chemical Properties

Molecular Weight	316.39
Formula	C₁₈H₁₇FO₂S
Cas No.	158959-32-1
Smiles	CS(=O)(=O)c1ccc(cc1)C1=C(CCC1)c1ccc(F)cc1
Relative Density.	1.253 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (284.46 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (10.43 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1607 mL	15.8033 mL	31.6066 mL	158.0328 mL
5 mM	0.6321 mL	3.1607 mL	6.3213 mL	31.6066 mL
10 mM	0.3161 mL	1.5803 mL	3.1607 mL	15.8033 mL
20 mM	0.1580 mL	0.7902 mL	1.5803 mL	7.9016 mL
50 mM	0.0632 mL	0.3161 mL	0.6321 mL	3.1607 mL
100 mM	0.0316 mL	0.1580 mL	0.3161 mL	1.5803 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc