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Anti-IL-1R1 Antibody-APC (3F72)
🥰Excellent
Catalog No. TMAY-03470A
Anti-IL-1R1 Antibody-APC (3F72) is a APC-conjugated Rabbit antibody targeting IL-1R1. Anti-IL-1R1 Antibody-APC (3F72) can be used in FCM.
Anti-IL-1R1 Antibody-APC (3F72)
Anti-IL-1R1 Antibody-APC (3F72)
🥰Excellent
Catalog No. TMAY-03470A
Anti-IL-1R1 Antibody-APC (3F72) is a APC-conjugated Rabbit antibody targeting IL-1R1. Anti-IL-1R1 Antibody-APC (3F72) can be used in FCM.
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Product Introduction
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Chemical Properties
| Description | Anti-IL-1R1 Antibody-APC (3F72) is a APC-conjugated Rabbit antibody targeting IL-1R1. Anti-IL-1R1 Antibody-APC (3F72) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 3F72 |
| Reactivity | Mouse |
| Verified Activity | Flow cytometric analysis of Mouse IL1R1(CD121a) expression on NIH/3T3 cells. NIH/3T3 cells were stained with APC-conjugated anti-mouse IL1R1(CD121a). The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | 10 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IL-1R1 / CD121a (rM IL-1R1 / CD121a; TMPY-02341; P13504; Met1-Lys338) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokines induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects. In the spleen, a slight increase in IL-1R ACP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess. |
| Conjucates | APC |
| Others Formats | Unconjugated/PE |
| Antibody Types Available | 3 |
| Immunogen | Recombinant Mouse IL-1R1 / CD121a protein (TMPY-02341) |
| Antigen Species | Mouse |
| Biology Area | Neuroinflammation |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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