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Anti-Renin Antibody (1Q991) is a Rabbit antibody targeting Renin. Anti-Renin Antibody (1Q991) can be used in ELISA,IHC-P.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 μL | 254 € | 7-10 days |
Description | Anti-Renin Antibody (1Q991) is a Rabbit antibody targeting Renin. Anti-Renin Antibody (1Q991) can be used in ELISA,IHC-P. |
Alias | renin, REN, HNFJ2, FLJ10761 |
Ig Type | Monoclonal Rabbit IgG |
Clone | 1Q991 |
Reactivity | Mouse |
Verified Activity | Immunochemical staining of mouse REN1 in mouse kidney with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to juxtaglomerular cell. The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein). |
Application | ELISA,IHC-P |
Recommended Dose | ELISA: 1:5000-1:10000; IHC-P: 1:100-1:500 |
Antibody Type | Monoclonal |
Host Species | Rabbit |
Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse REN1 (rM REN1; TMPY-01231; NP_112469.1; Met 1-Arg 402). |
Purification | Protein A |
Appearance | Liquid |
Formulation | 0.2 μm filtered solution in PBS |
Research Background | Renin-1, also known as Ren-1, Angiotensinogenase and Kidney renin, is a member of the peptidase A1 family. Renin-1 is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sodium concentration. androgen and thyroid hormones influence levels of Renin-1 in mouse submandibular gland (SMG) primarily by regulating the amount of Renin-1 mRNA available for translation. Renin-1 is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. It is expressed at relatively low levels in mouse SMG and kidney. Ren-2 is expressed at high levels in the mouse SMG and at very low levels, if at all, in the kidney. Ren-1 and Ren-2 are closely linked on mouse chromosome 1, show extensive homology in coding and noncoding regions and provide a model for studying the regulation of gene expression. |
Conjucates | Unconjugated |
Immunogen | Recombinant Mouse REN1 protein (TMPY-01231) |
Antigen Species | Mouse |
Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
Transport | Shipping with blue ice. |
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