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GRK2 Inhibitor (Synonyms: βARK1 Inhibitor)

Name: GRK2 Inhibitor
Brand: TargetMol
SKU: T25464
Price: 139 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T25464 Copy Product Info

Purity: 98.46%

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GRK2 Inhibitor is an effective GRK2 inhibitor. It enhances GPCR signaling by preventing receptor desensitization, used for heart failure and cardiovascular remodeling research.

GRK2 Inhibitor

Copy Product Info

🥰Excellent

Catalog No. T25464

Synonyms βARK1 Inhibitor

GRK2 Inhibitor is an effective GRK2 inhibitor. It enhances GPCR signaling by preventing receptor desensitization, used for heart failure and cardiovascular remodeling research.

Cas No. 24269-96-3

Pack Size	Price	USA Stock	Global Stock	Quantity
1 mL x 10 mM (in DMSO)	$139	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.46%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	GRK2 Inhibitor is an effective GRK2 inhibitor. It enhances GPCR signaling by preventing receptor desensitization, used for heart failure and cardiovascular remodeling research.
In vitro	GRK2 Inhibitor (CMPD101) blocks agonist-induced smooth muscle contractions [3].; Locostatin induces death in CLL cells [2].
In vivo	Modulating GRK2 levels with GRK2 Inhibitor alters sensitization in rat pain models; low GRK2 underlies hyperalgesic priming [1].
Synonyms	βARK1 Inhibitor

Chemical Properties

Molecular Weight	263.2
Formula	C₁₂H₉NO₆
Cas No.	24269-96-3
Smiles	O=C(C1=CC=C(C=CC2=CC=C([N+]([O-])=O)O2)O1)OC
Relative Density.	1.400 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 33 mg/mL (125.38 mM), Sonication is recommmended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7994 mL	18.9970 mL	37.9939 mL	189.9696 mL
5 mM	0.7599 mL	3.7994 mL	7.5988 mL	37.9939 mL
10 mM	0.3799 mL	1.8997 mL	3.7994 mL	18.9970 mL
20 mM	0.1900 mL	0.9498 mL	1.8997 mL	9.4985 mL
50 mM	0.0760 mL	0.3799 mL	0.7599 mL	3.7994 mL
100 mM	0.0380 mL	0.1900 mL	0.3799 mL	1.8997 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc