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Fusaric acid

Name: Fusaric acid
Brand: TargetMol
SKU: Fr12377
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Fusaric acid is an orally active multi-target inhibitor capable of inhibiting fibrosis-related signaling pathways such as NF-κB, TGF-β1/SMADs, and PI3K/AKT/mTOR. It also inhibits dopamine β-hydroxylase and reduces endogenous levels of norepinephrine and epinephrine. Fusaric acid activates apoptosis-related proteases such as Caspase-3/7, Caspase-8, and Caspase-9, thereby inducing oxidative stress and apoptosis. It chelates divalent metal cations, damages mitochondrial membrane structure, and exerts effects in improving myocardial fibrosis and alleviating cardiac hypertrophy. Additionally, it is applicable in research on esophageal cancer, liver cancer, and other conditions.

Cas No. 536-69-6

Pack Size	Price	USA Stock	Global Stock	Quantity
25 mg	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$35	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Fusaric acid is an orally active multi-target inhibitor capable of inhibiting fibrosis-related signaling pathways such as NF-κB, TGF-β1/SMADs, and PI3K/AKT/mTOR. It also inhibits dopamine β-hydroxylase and reduces endogenous levels of norepinephrine and epinephrine. Fusaric acid activates apoptosis-related proteases such as Caspase-3/7, Caspase-8, and Caspase-9, thereby inducing oxidative stress and apoptosis. It chelates divalent metal cations, damages mitochondrial membrane structure, and exerts effects in improving myocardial fibrosis and alleviating cardiac hypertrophy. Additionally, it is applicable in research on esophageal cancer, liver cancer, and other conditions.
In vitro	Methods: HepG2 human hepatocellular carcinoma cells were treated with fusaric acid at concentrations of 25, 50, 104, and 150 µg/mL for 24 hours. The levels of 5-methylcytosine (5-mC) were measured using a colorimetric assay, and the mRNA expression levels of DNMT1, DNMT3A, and DNMT3B were assessed by qPCR. Results: Fusaric acid dose-dependently reduced global DNA methylation levels, induced hypomethylation, and significantly decreased the mRNA expression of DNMT1, DNMT3A, and DNMT3B. [1] Methods: H9C2 cells were treated with 160 μM fusaric acid and 10 μM isoprenaline (ISP) for a total of 24 hours. Cell size was assessed by immunofluorescence staining; ANP, BNP, β-MHC, and TRPC6 expression levels were measured by qPCR and Western blot. Results: Fusaric acid significantly inhibited ISP-induced increases in cell area while downregulating the expression of ANP, BNP, β-MHC, and TRPC6.[2] Methods: Primary mouse cardiac fibroblasts were treated with 0–160 μM fusaric acid and preincubated for 1 hour, then co-treated with 10 μM ISP for 24 hours. Western blot analysis was performed to detect the expression levels of α-SMA, collagen I, and collagen III. Results: Fusaric acid dose-dependently inhibited ISP-induced collagen expression and reduced the expression levels of fibrosis-related genes. [2]
In vivo	Methods: To investigate the effects of fusaric acid on ISP-induced myocardial hypertrophy, C57BL/6 mice were administered fusaric acid (50, 100 mg/kg) via oral gavage for 7 days, followed by concurrent treatment with ISP (150 mg/kg/day, subcutaneous injection) for 7 days. Results: Fusaric acid attenuated ISP-induced myocardial tissue damage, collagen deposition, and cardiomyocyte hypertrophy. Fusaric acid also inhibited ISP-induced TGF-β1 expression and the phosphorylation of SMAD2/3, p38, ERK1/2, and JNK. [2]

Chemical Properties

Molecular Weight	179.22
Formula	C₁₀H₁₃NO₂
Cas No.	536-69-6
Smiles	O=C(O)C1=NC=C(C=C1)CCCC
Relative Density.	1.113g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 46.66 mg/mL (260.35 mM), Sonication is recommended.

H2O: 40 mg/mL (223.19 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.5797 mL	27.8987 mL	55.7973 mL	278.9867 mL
5 mM	1.1159 mL	5.5797 mL	11.1595 mL	55.7973 mL
10 mM	0.5580 mL	2.7899 mL	5.5797 mL	27.8987 mL
20 mM	0.2790 mL	1.3949 mL	2.7899 mL	13.9493 mL
50 mM	0.1116 mL	0.5580 mL	1.1159 mL	5.5797 mL
100 mM	0.0558 mL	0.2790 mL	0.5580 mL	2.7899 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.