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GSK-3β inhibitor 12
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Catalog No. T60472Cas No. 784170-07-6
GSK-3β inhibitor 12 is a selective GSK-3β inhibitor.GSK-3β inhibitor 12 inhibits 49.11% of 25 μM GSK-3β activity and 37.11% of 50 μM GSK-3β activity.GSK-3β inhibitor 12 can be used for the study of Parkinson's in the presence of lipopolysaccharide induction.
GSK-3β inhibitor 12
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Purity: 98.58%
Catalog No. T60472Cas No. 784170-07-6
GSK-3β inhibitor 12 is a selective GSK-3β inhibitor.GSK-3β inhibitor 12 inhibits 49.11% of 25 μM GSK-3β activity and 37.11% of 50 μM GSK-3β activity.GSK-3β inhibitor 12 can be used for the study of Parkinson's in the presence of lipopolysaccharide induction.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $33 | - | In Stock | |
| 5 mg | $77 | - | In Stock | |
| 10 mg | $128 | - | In Stock | |
| 25 mg | $223 | - | In Stock | |
| 50 mg | $317 | - | In Stock | |
| 100 mg | $442 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.58%
Appearance:Solid
Color:Yellow
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Product Introduction
GSK-3β inhibitor 12 AI Summary
GSK-3β inhibitor 12 exhibits a diverse range of bioactivities based on various assays. It demonstrates inhibitory potency in assays related to aggregate formation in a Huntington cell model, Aldehyde Dehydrogenase 1, lipid storage in Drosophila cells, Tau fibril formation, human muscle isoform 2 pyruvate kinase, N370S glucocerebrosidase, chronic active B-cell receptor signaling, BAZ2B, and ELG1-dependent DNA repair. Additionally, it acts as an activator in assays involving re-activation of p53 using a luciferase reporter. Moreover, GSK-3β inhibitor 12 shows agonist activity in assays for gsp, synthetic lethality induction in tumor cells producing 2HG, and as an antiviral for Foot and Mouth Disease Virus..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | GSK-3β inhibitor 12 is a selective GSK-3β inhibitor.GSK-3β inhibitor 12 inhibits 49.11% of 25 μM GSK-3β activity and 37.11% of 50 μM GSK-3β activity.GSK-3β inhibitor 12 can be used for the study of Parkinson's in the presence of lipopolysaccharide induction. |
| Molecular Weight | 271.34 |
| Formula | C14H13N3OS |
| Cas No. | 784170-07-6 |
| Smiles | CC1=CN=C(NC(=O)CC2=CNC3=CC=CC=C23)S1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (184.27 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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