Flosulide

Name: Flosulide
Brand: TargetMol
SKU: T11296
Rating: 4.5 (1 reviews)

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Catalog No. T11296Cas No. 80937-31-1

Alias ZK 38997, CGP 28238

Flosulide is an effective selective COX-2 inhibitor for the treatment of inflammatory diseases.

Flosulide

😃Good

Catalog No. T11296Alias ZK 38997, CGP 28238Cas No. 80937-31-1

Flosulide is an effective selective COX-2 inhibitor for the treatment of inflammatory diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,670	6-8 weeks	6-8 weeks
50 mg	$2,180	6-8 weeks	6-8 weeks
100 mg	$2,800	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Flosulide is an effective selective COX-2 inhibitor for the treatment of inflammatory diseases.
In vitro	Flosulide entirely inhibits the mitotic activity of OSC-2 cells while having no impact on the mitotic activity of OSC-1 cells. Additionally, Flosulide demonstrates a concentration-dependent effect on the OSC-2 cell line by fully suppressing PGE2 production across a range of 1 nM to 100 μM; however, it does not affect prostaglandin (PG) synthesis in OSC-1 cells.
In vivo	In normovolemic rats, flosulide enhances renal plasma flow (RPF) and glomerular filtration rate (GFR), while in hypovolemic rats, it reduces these measures at dosages between 5-25 mg/kg. At a dosage of 5 mg/kg, flosulide lowers 6-keto-PGF1alpha, and at 25 mg/kg or following 10 mg/kg of indomethacin, it leads to a decrease in both 6-keto-PGF1alpha and TXB2[1]. Furthermore, flosulide at 0.75 mg/day notably decreases proteinuria compared to aspirin treatment and results in significantly higher plasma protein and albumin levels than those observed in aspirin-treated rats[3].
Synonyms	ZK 38997, CGP 28238

Chemical Properties

Molecular Weight	353.34
Formula	C₁₆H₁₃F₂NO₄S
Cas No.	80937-31-1
Smiles	O(C1=C(NS(C)(=O)=O)C=C2C(=C1)C(=O)CC2)C3=C(F)C=C(F)C=C3
Relative Density.	1.506g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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