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AS057278

🥰Excellent
Catalog No. T7476Cas No. 402-61-9
Alias 3-Methylpyrazole-5-carboxylic acid

AS057278 (3-Methylpyrazole-5-carboxylic acid) is an D-amino acid oxidase (DAAO) inhibitor.

AS057278

AS057278

🥰Excellent
Purity: 97.80%
Catalog No. T7476Alias 3-Methylpyrazole-5-carboxylic acidCas No. 402-61-9
AS057278 (3-Methylpyrazole-5-carboxylic acid) is an D-amino acid oxidase (DAAO) inhibitor.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$30In StockIn Stock
10 mg$48In StockIn Stock
25 mg$79In StockIn Stock
50 mg$119In StockIn Stock
100 mg$177In StockIn Stock
200 mg$263-In Stock
1 mL x 10 mM (in DMSO)$33In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:97.80%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
AS057278 (3-Methylpyrazole-5-carboxylic acid) is an D-amino acid oxidase (DAAO) inhibitor.
In vivo
AS057278 was able to normalize phencyclidine (PCP)-induced prepulse inhibition after acute (80 mg/kg) and chronic (20 mg/kg b.i.d.) oral administration in mice.?AS057278 after oral chronic treatment (10 mg/kg b.i.d.) was able to normalize PCP-induced hyperlocomotion.?AS057278 has the potential to anti-psychotic action toward both cognitive and positive symptoms of schizophrenia[1].
Synonyms3-Methylpyrazole-5-carboxylic acid
Chemical Properties
Molecular Weight126.11
FormulaC5H6N2O2
Cas No.402-61-9
SmilesCC1=CC(=NN1)C(O)=O
Relative Density.1.404g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 25 mg/mL (198.24 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (15.86 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM7.9296 mL39.6479 mL79.2959 mL396.4793 mL
5 mM1.5859 mL7.9296 mL15.8592 mL79.2959 mL
10 mM0.7930 mL3.9648 mL7.9296 mL39.6479 mL
20 mM0.3965 mL1.9824 mL3.9648 mL19.8240 mL
50 mM0.1586 mL0.7930 mL1.5859 mL7.9296 mL
100 mM0.0793 mL0.3965 mL0.7930 mL3.9648 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SchizophreniaPrepulse inhibitionOrally activeNon-peptidicInhibitorinhibitD-amino acid oxidase (DAAO)D-amino acid oxidaseBBB penetrantAS-057278AS057278AS 057278
Related Tags: buy AS057278 | purchase AS057278 | AS057278 cost | order AS057278 | AS057278 chemical structure | AS057278 in vivo | AS057278 formula | AS057278 molecular weight
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