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Suzetrigine

Name: Suzetrigine
Brand: TargetMol
SKU: T69552
Price: 53 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: VX-548) Copy Product Info

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Synonyms: VX-548

Catalog No. T69552 Copy Product Info

Purity: 99.87%

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Suzetrigine (VX-548) is a small molecule inhibitor and a highly selective inhibitor of the NaV1.8 target, with oral activity and good peripheral nerve selectivity. Suzetrigine is used for the treatment of moderate to severe acute pain following abdominoplasty or bunionectomy.

Cas No. 2649467-58-1

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Pack Size	Price	USA Stock	Global Stock
1 mg	$53	In Stock	In Stock
5 mg	$116	In Stock	In Stock
10 mg	$173	In Stock	In Stock
25 mg	$281	In Stock	In Stock
50 mg	$482	In Stock	In Stock
100 mg	$786	In Stock	In Stock
200 mg	$1,080	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$120	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.87%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Suzetrigine (VX-548) is a small molecule inhibitor and a highly selective inhibitor of the NaV1.8 target, with oral activity and good peripheral nerve selectivity. Suzetrigine is used for the treatment of moderate to severe acute pain following abdominoplasty or bunionectomy.
Targets & IC50	NaV1.8 (dog):740 nM, NaV1.8:0.7 nM, NaV1.8 (mouse):210 nM, NaV1.8 (rabbit):52 nM, NaV1.8 (rat):56 nM, Nav1.8 (human):0.68 ± 0.16 nM, NaV1.8 (monkey):0.75 nM
In vitro	Methods: The inhibitory effect of Suzetrigine was evaluated using automated patch-clamp in HEK, CHO, or ND7/23 cells expressing Nav1.8, and manual patch-clamp in human primary DRG neurons, with incubation at 1–10 nM for 2–10 minutes. Results: Suzetrigine selectively inhibited Nav1.8 with sub-nanomolar potency (IC50 = 0.68 nM) and concentration-dependently suppressed action potential firing in DRG neurons. [1]
In vivo	Methods: In patients following abdominoplasty or bunionectomy, Suzetrigine was administered at the highest dose (initial oral dose of 100 mg, followed by 50 mg every 12 hours) or a lower dose (initial dose of 20 mg, followed by 10 mg every 12 hours) and compared with placebo to observe changes in acute pain over 48 hours. Results: Compared with placebo, Suzetrigine reduced acute pain within 48 hours after surgery only at the highest dose.[1]
Synonyms	VX-548

Chemical Properties

Molecular Weight	473.39
Formula	C₂₁H₂₀F₅N₃O₄
Cas No.	2649467-58-1
Smiles	C(NC=1C=C(C(N)=O)N=CC1)(=O)[C@H]2[C@@H]([C@H](C)[C@@]([C@@](F)(F)F)(C)O2)C3=C(OC)C(F)=C(F)C=C3

Storage & Solubility Information

Storage

Store at low temperature,Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 161 mg/mL (340.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1124 mL	10.5621 mL	21.1242 mL	105.6212 mL
5 mM	0.4225 mL	2.1124 mL	4.2248 mL	21.1242 mL
10 mM	0.2112 mL	1.0562 mL	2.1124 mL	10.5621 mL
20 mM	0.1056 mL	0.5281 mL	1.0562 mL	5.2811 mL
50 mM	0.0422 mL	0.2112 mL	0.4225 mL	2.1124 mL
100 mM	0.0211 mL	0.1056 mL	0.2112 mL	1.0562 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.