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Suzetrigine

Name: Suzetrigine
Brand: TargetMol
SKU: T69552
Price: 53 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T69552Cas No. 2649467-58-1

Alias VX-548

Suzetrigine(VX-548) is an orally active and specific NaV1.8 inhibitor. Suzetrigine has analgesic activity and can be used to study acute pain and neurotransmission.

Suzetrigine

🥰Excellent

Purity: 99.27%

Catalog No. T69552Alias VX-548Cas No. 2649467-58-1

Suzetrigine(VX-548) is an orally active and specific NaV1.8 inhibitor. Suzetrigine has analgesic activity and can be used to study acute pain and neurotransmission.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$53	In Stock	In Stock
5 mg	$116	In Stock	In Stock
10 mg	$173	In Stock	In Stock
25 mg	$281	In Stock	In Stock
50 mg	$482	In Stock	In Stock
100 mg	$786	In Stock	In Stock
200 mg	$1,080	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$120	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.27%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Suzetrigine(VX-548) is an orally active and specific NaV1.8 inhibitor. Suzetrigine has analgesic activity and can be used to study acute pain and neurotransmission.
Targets&IC50	NaV1.8 (rabbit):52 nM, NaV1.8 (mouse):210 nM, NaV1.8 (dog):740 nM, Nav1.8 (human):0.68 ± 0.16 nM, NaV1.8:0.7 nM, NaV1.8 (monkey):0.75 nM, NaV1.8 (rat):56 nM
In vivo	As compared with placebo, Suzetrigine at the highest dose (a 100-mg oral loading dose of Suzetrigine, followed by a 50-mg maintenance dose every 12 hours), but not at lower doses (a 20-mg loading dose, followed by a 10-mg maintenance dose every 12 hours), reduced acute pain over a period of 48 hours after abdominoplasty or bunionectomy.[1]
Synonyms	VX-548

Chemical Properties

Molecular Weight	473.39
Formula	C₂₁H₂₀F₅N₃O₄
Cas No.	2649467-58-1
Smiles	C(NC=1C=C(C(N)=O)N=CC1)(=O)[C@H]2[C@@H]([C@H](C)[C@@]([C@@](F)(F)F)(C)O2)C3=C(OC)C(F)=C(F)C=C3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 161 mg/mL (340.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1124 mL	10.5621 mL	21.1242 mL	105.6212 mL
5 mM	0.4225 mL	2.1124 mL	4.2248 mL	21.1242 mL
10 mM	0.2112 mL	1.0562 mL	2.1124 mL	10.5621 mL
20 mM	0.1056 mL	0.5281 mL	1.0562 mL	5.2811 mL
50 mM	0.0422 mL	0.2112 mL	0.4225 mL	2.1124 mL
100 mM	0.0211 mL	0.1056 mL	0.2112 mL	1.0562 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc