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Parasite

Parasites include protozoans such as the agents of malaria, sleeping sickness, and amoebic dysentery; animals such as hookworms, lice, mosquitoes, and vampire bats; fungi such as honey fungus and the agents of ringworm; and plants such as mistletoe, dodder, and the broomrapes. There are six major parasitic strategies of exploitation of animal hosts, namely parasitic castration, directly transmitted parasitism (by contact), trophically transmitted parasitism (by being eaten), vector-transmitted parasitism, parasitoidism, and micropredation.

  • Chloroquine
    T868954-05-7
    Chloroquine is a Toll-like receptor inhibitor that inhibits autophagy. Chloroquine has anti-malarial and anti-inflammatory activity and is widely used in the treatment of malaria and rheumatoid arthritis. Chloroquine also has anti-SARS-CoV-2 (COVID-19) activity and anti-HIV-1 activity.
    • $43.2
    • $54
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  • Doxycycline
    T1687564-25-0
    Doxycycline (Doxiciclina) belongs to the tetracycline class of antibiotics and is a broad-spectrum metalloproteinase (MMP) inhibitor with oral activity. Doxycycline has antibacterial activity and antitumor activity.
    • $45
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  • Hypocrellin A
    T577177029-83-5
    Hypocrellin A is PKC inhibitor, has light-induced antitumor,antifungal and antiviral activities, it also exerts immunomodulatory effects on MHC-restricted presentation of antigen.
    • $47
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  • Dinitolmide
    T0873148-01-6
    Dinitolmide (Zoalene), a poultry feed additive, is a coccidiostat for poultry.
    • $38
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  • Benzyl benzoate
    T0729120-51-4
    Benzyl benzoate (Benzoic acid benzyl ester) is one of the older preparations used for the therapy of scabies. Scabies is a skin infection caused by the Sarcoptes scabiei. Its symptoms are red spots, severe itching (particularly at night), and may lead to a secondary infection. Benzyl benzoate is useful in the therapy of scabies because it is lethal to this mite. It is also used for the therapy of lice affection of the body and head. Benzyl benzoate is not the therapy of choice for scabies because of its irritant properties.
    • $31
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  • Picaridin
    T16531119515-38-7
    Picaridin (Lcaridin) is a topical insect repellent.
    • $41
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  • Closantel
    T023757808-65-8
    Closantel (R-31520), a salicylanilide anthelmintic compound, shows different anthelmintic spectra and obvious toxicity in mammals.
    • $34
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  • Asiatic acid
    T2827464-92-6
    Asiatic acid (Dammarolic acid) is the aglycone of asiaticoside used in wound healing with antioxidant, anti-inflammatory, and neuroprotective properties.
    • $30
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    TargetMol | Citations Cited
  • Dihydroartemisinin
    T060771939-50-9
    Dihydroartemisinin (Artenimol) is a metabolite of artemisinin.
    • $33
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    TargetMol | Citations Cited
  • Flubendazole
    T000931430-15-6
    Flubendazole (Flumoxane) is available OTC in Europe that is an anthelmintic using to treat worm infection in humans.
    • $50
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  • λ-Cyhalothrin
    T2779491465-08-6
    λ-Cyhalothrin (Icon) is a type II synthetic pyrethroid insecticide featuring a high-efficiency, broad-spectrum formula with an α-cyano group. It is employed across various applications for controlling a wide array of pests. As a neurotoxin, λ-Cyhalothrin acts on sodium channels in neuron membranes within the central nervous system.
    • $41
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  • Chloroquine phosphate
    T019450-63-5
    Chloroquine phosphate (Aralen phosphate) is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs).
    • $42
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    TargetMol | Citations Cited
  • Nitazoxanide
    T154655981-09-4
    Nitazoxanide (NSC-697855) is a synthetic benzamide with antiprotozoal activity. Nitazoxanide exerts its antiprotozoal activity by interfering with the pyruvate ferredoxin/flavodoxin oxidoreductase dependent electron transfer reaction.
    • $30
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  • Artemotil
    T332775887-54-6
    Artemotil (SM-227) is a new, fast-acting antimalarial drug.
    • $50
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    TargetMol | Citations Cited
  • Amprolium Hydrochloride
    T0872L137-88-2
    Amprolium Hydrochloride (Amprolium HCl) is a coccidiostat that interferes with thiamine metabolism.
    • $51
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  • ZY-19489
    T676941821293-40-6In house
    ZY-19489 is an antimalarial compound that is a potential single-dose cure for Plasmodium falciparum and Plasmodium vivax malaria. It has received orphan drug designation from the FDA.
    • $365
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  • DL-Methionine
    TJO274259-51-8
    DL-Methionine (Acimetion) is an amino acid. Amino acids are the building blocks that our bodies use to make proteins. DL-Methionine is found in meat, fish, and dairy products. It plays an important role in the many functions within the body.
    • $41
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  • Sanguinarine chloride
    T01295578-73-4
    Sanguinarine chloride (Pseudochelerythrine chloride), a benzophenanthridine alkaloid, stimulates apoptosis by activating the production of reactive oxygen species (ROS).
    • $50
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  • Hydroxychloroquine
    T9287118-42-3
    Hydroxychloroquine (2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol) (HCQ) is an alkalinizing lysosomatropic drug that acts by inducing apoptosis of renal cancer cells in vitro and inhibiting TLR7/9. It is a medication used to prevent and treat malaria, and it's also being studied as an experimental treatment for COVID-19.
    • $30
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    TargetMol | Citations Cited
  • Dixanthogen
    T1268502-55-6
    Dixanthogen (Auligen) is an ectoparasiticide. Dixanthogen is a thiocarbonyl compound.
    • $42
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  • Diethyltoluamide
    T0731134-62-3
    Diethyltoluamide (DEET) is the most general active composition in insect repellents.
    • $41
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  • Harpagide
    T6S20246926-08-5
    1. Harpagide has antibacterial activity. 2. Harpagide has antiviral activity. 3. Harpagide has anti-inflammatory activity.
    • $130
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  • Sulfalene
    T0026152-47-6
    Sulfalene (SMP2), a long-acting sulfonamide antibiotic, is used for the therapy of chronic bronchitis, urinary tract infections, and malaria.
    • $40
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  • α-Terpinene
    T790999-86-5
    α-Terpinene is a terpenoid,has acaricidal, antiprotozoal, and antioxidant properties
    • $41
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  • Artemisinin
    T039263968-64-9
    Artemisinin (Qinghaosu) is an ancient Chinese herbal therapy for malarial fevers which has been recently found to have potent activity against many forms of malarial organisms, including chloroquine-resistant Plasmodium falciparum.
    • $30
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    TargetMol | Citations Cited
  • Kaempferol
    T2177520-18-3
    Kaempferol (Robigenin) is a natural flavonoid and an inverse agonist of ERRα and ERRγ. Kaempferol has a wide range of antitumor, anti-inflammatory, antioxidant, antibacterial and antiviral activities.
    • $46
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    TargetMol | Citations Cited
  • nerolidol
    T2S21727212-44-4
    Nerolidol (Peruviol) shows sedative effects in animals, oxidative process plays a crucial role on neuronal pathological consequence. Nerolidol is mainly related to ROS and DNA single strand breaks generated by the presence of oxidative lesions.
    • $29
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  • PHYTOL
    T3254150-86-7
    PHYTOL (trans-Phytol) , a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects. It is a specific activator of PPARα.
    • $42
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  • CpCDPK1/TgCDPK1-IN-2
    T720811236038-23-5In house
    CpCDPK1/TgCDPK1-IN-2 is a dual inhibitor of CpCDPK1 and TgCDPK1 with IC50 values of 12 and 5 nM for CpCDPK1 and TgCDPK1, respectively.CpCDPK1/TgCDPK1-IN-2 can be used in the study of diseases associated with infection of toxoplasmas such as Toxoplasma gondii, Cryptosporidium parvum and C. hominus. CpCDPK1/TgCDPK1-IN-2 can be used to study diseases associated with infections of toxoplasma gondii (T. gondii), Cryptosporidium parvum (C. parvum), and Cryptosporidium hominus (C. hominus).
    • $350
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  • Antimalarial agent 13
    T9984431884-01-4
    Antimalarial agent 13 (N2-(3-chlorophenyl)-N4-(furan-2-ylmethyl)quinazoline-2,4-diamine) is a potent antimalarial agent.
    • $195
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  • UCB7362 hydrochloride
    T69567L2610631-18-8In house
    UCB7362 hydrochloride (UCB7362 HCl) is an orally active plasmepsin X (PMX) inhibitor (IC50: 7 nM) with antimalarial activity that inhibits parasite growth.
    • $195
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  • pCDPK1/TgCDPK1-IN-3
    T720331092788-87-8In house
    CpCDPK1/TgCDPK1-IN-3 is a dual inhibitor of CpCDPK1 and TgCDPK1 with an IC50 of 0.003 µM for CpCDPK1 and 0.0036 µM for TgCDPK1. CpCDPK1/TgCDPK1-IN-3 can be used to study infections associated with diseases such as Toxoplasma, Cryptosporidium and Cryptosporidium.
    • $84
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  • Carnidazole
    T2053542116-76-7
    Carnidazole (ME-108) shows antiprotozoal activity and can be used in studies about the treatment of Trichomonas infection.
    • $50
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  • UCB7362
    T695672610631-17-7In house
    UCB7362 (GLXC-26743) is an orally available and potent plasmepsin X (PMX) inhibitor with anti-malarial activity.UCB7362 inhibits parasite reproduction.
    • $579
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  • MMV688533
    T676952260904-47-8In house
    MMV688533 has antimalarial activity.
    • $195
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  • Homobutein
    TN422034000-39-0
    Homobutein (3-O-Methylbutein) is a dual inhibitor of HDACs and NF-κB with IC50s of 190 and 38 μM. Homobutein is an iron chelator with anticancer, anti-inflammatory, antiparasite, and antioxidation activities.
    • $195
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  • Cletoquine hydrochloride
    T10835L1159358-29-9In house
    Cletoquine hydrochloride is a major active metabolite of Hydroxychloroquine. Cletoquine hydrochloride is a Chloroquine derivative and exhibits the ability to against the chikungunya virus (CHIKV). Cletoquine hydrochloride exhibits antimalarial effects.
    • $197
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  • YCN47284
    T9591181147-28-4
    YCN47284 is an antimalarial compound with an IC50 of 1 μM for P. falciparum.
    • $48
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  • Leu-Val
    T8066513588-95-9
    Leu-Val (L-leucyl-L-valine) is a novel potent dipeptide with antibacterial and antimalarial activity.
    • $33
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  • Brotianide
    T3059623233-88-7In house
    Brotianide (BAY-VA4059) has anthelmintic activity and is highly potent against liver fluke and gastric fluke infestations and can be used to treat acute, subacute and chronic liver fascioliasis infections in sheep.
    • $258
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  • D-Phenothrin
    T1363326046-85-5
    D-Phenothrin ((-)-trans-Phenothrin) is used in veterinary medicine to control pests on animals and to protect crops. D-Phenothrin is an orally effective type II synthetic pyrethroid widely used to kill insects, mosquitoes and human lice.
    • $51
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  • T-0156
    T23411L324572-92-1In house
    T-0156 is a novel, potent and selective phosphodiesterase type 5 inhibitor that inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) with low affinity for PDE6, PDE1, PDE2, PDE3 and PDE4.
    • $195
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  • 4-(2-Aminoethyl)amino-7-chloroquinoline
    T776845407-57-8
    4-(2-Aminoethyl)amino-7-chloroquinoline (N1-(7-Chloroquinolin-4-yl)ethane-1,2-diamine) has potential anthelmintic and antitumor activity for the study of malaria.
    • $33
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  • Antitrypanosomal agent 2
    T10340475626-30-3In house
    Antitrypanosomal agent 2 shows potent and specific antiparasite activities against Trypanosoma brucei.
    • $329
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  • Antimalarial agent 30
    T795351597425-64-3In house
    Antimalarial agent 30 has anti-Plasmodium berghei liver stage parasite activity and antimalarial activity for the study of malarial infections.
    • $195 TargetMol
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  • Sulmazole
    T2888173384-60-8In house
    Sulmazole (AR-L 115-BS) is a small molecule Sulmazole is a small molecule cGMP-PDE inhibitor.Sulmazole is a competitive inhibitor of A1 adenosine receptors.Sulmazole has been shown to improve cardiac index, low pulmonary capillary wedge pressure, and can be used in the study of heart failure.Sulmazole is a small molecule cGMP-PDE inhibitor.
    • $32
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  • DNDI-6148
    T397462243909-59-1In house
    DNDI-6148 has anti-experimental cutaneous leishmaniasis activity and can be used to study visceral leishmaniasis by inhibiting Leishmania protozoa cleavage and polyadenylation-specific factor (CPSF3) endonuclease.
    • $293 TargetMol
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  • Tioxazafen
    T13928330459-31-9
    Tioxazafen is a disubstituted oxadiazole, and is a broad-spectrum seed treatment nematicide.
    • $31
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  • 2'-Hydroxy-3,4-dimethoxychalcone
    TN722519152-36-4
    2'-Hydroxy-3,4-dimethoxychalcone, a chalcone compound isolated from the roots of Sophora japonica, has antioxidant activity and inhibited the intracellular survival of Lactobacillus donovani Parasite EC.50 Values ranged between 0.39 and 0.41 μg/mL, which can be used in the study of diabetes, treatment of schistosomiasis, malaria and other infections.
    • $50
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  • Pentamidine dihydrochloride
    T2313250357-45-4In house
    Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an aromatic diamidine agent with activity against a number of microorganisms including protozoa (Trypanosoma brucei, Leishmania spp., and Babesia spp.) and fungi (Pneumocystis jirovecii). Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases and phosphatase of regenerating liver inhibitor. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM.
    • $50
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