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EAI001

Name: EAI001
Brand: TargetMol
SKU: T61191
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T61191Cas No. 892772-75-7

EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.EAI001 can be used in cancer research.

EAI001

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Purity: 99.94%

Catalog No. T61191Cas No. 892772-75-7

EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.EAI001 can be used in cancer research.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$51	-	In Stock
10 mg	$89	-	In Stock
25 mg	$178	-	In Stock
50 mg	$297	-	In Stock
100 mg	$478	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.94%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.EAI001 can be used in cancer research.
Targets&IC50	EGFR (L858R/T790M):24 nM
In vitro	EAI001 (50 μM) exhibits binding to EGFR T790M/C797S/V948R, situated deep within the EGFR near the ATP binding site and the C-helix. The inhibitory activity of EAI001 is attributed to its hydrophobic interactions with amino acids Ile759, Leu747, Leu788, Leu777, and Met766.[1]

Chemical Properties

Molecular Weight	349.41
Formula	C₁₉H₁₅N₃O₂S
Cas No.	892772-75-7
Smiles	O=C(Nc1nccs1)C(N1Cc2ccccc2C1=O)c1ccccc1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (257.58 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.44 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8620 mL	14.3098 mL	28.6197 mL	143.0984 mL
5 mM	0.5724 mL	2.8620 mL	5.7239 mL	28.6197 mL
10 mM	0.2862 mL	1.4310 mL	2.8620 mL	14.3098 mL
20 mM	0.1431 mL	0.7155 mL	1.4310 mL	7.1549 mL
50 mM	0.0572 mL	0.2862 mL	0.5724 mL	2.8620 mL
100 mM	0.0286 mL	0.1431 mL	0.2862 mL	1.4310 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc