Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.EAI001 can be used in cancer research.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 51.00 | |
10 mg | In stock | $ 89.00 | |
25 mg | In stock | $ 178.00 | |
50 mg | In stock | $ 297.00 | |
100 mg | In stock | $ 478.00 |
Description | EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.EAI001 can be used in cancer research. |
Targets&IC50 | EGFR (L858R/T790M):24 nM |
In vitro | EAI001 (50 μM) exhibits binding to EGFR T790M/C797S/V948R, situated deep within the EGFR near the ATP binding site and the C-helix. The inhibitory activity of EAI001 is attributed to its hydrophobic interactions with amino acids Ile759, Leu747, Leu788, Leu777, and Met766.[1] |
Molecular Weight | 349.41 |
Formula | C19H15N3O2S |
CAS No. | 892772-75-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (257.58 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
EAI001 892772-75-7 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR inhibitor inhibit