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Phellamurin

Name: Phellamurin
Brand: TargetMol
SKU: TN4761
Price: 166 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN4761Cas No. 52589-11-4

Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadministration of Phellamurin or Phellodendron wilsonii with cyclosporin should be avoided.

Phellamurin

🥰Excellent

Purity: 97.91%

Catalog No. TN4761Cas No. 52589-11-4

Pack Size	Price	Availability
1 mg	$166	In Stock
5 mg	$337	In Stock
10 mg	$497	In Stock
25 mg	$793	In Stock
50 mg	$1,130	In Stock
100 mg	$1,520	In Stock
1 mL x 10 mM (in DMSO)	$432	In Stock

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Batch Information

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Purity:97.91%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadministration of Phellamurin or Phellodendron wilsonii with cyclosporin should be avoided.
In vitro	Administration of 0-10?μg/mL Phellamurin for 48 hours in U2OS and Saos-2?cells leads to a repression of cell viability dose-dependently, promotes the apoptosis of U2OS and Saos-2?cells concentration-dependently, and declines the ratios of p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR in U2OS and Saos-2?cells[1].
In vivo	Intraperitoneal injection of 50?mg/kg/day Phellamurin daily for 21 days in female BALB/c nude mice represses osteosarcoma tumor growth in vivo. The ratios of p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR are decreased in xenograft in Phellamurin-treated mice[1].

Chemical Properties

Molecular Weight	518.51
Formula	C₂₆H₃₀O₁₁
Cas No.	52589-11-4
Smiles	C(C=C(C)C)C1=C2C(C(=O)[C@H](O)[C@H](O2)C3=CC=C(O)C=C3)=C(O)C=C1O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O
Relative Density.	1.504 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (106.07 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9286 mL	9.6430 mL	19.2860 mL	96.4302 mL
5 mM	0.3857 mL	1.9286 mL	3.8572 mL	19.2860 mL
10 mM	0.1929 mL	0.9643 mL	1.9286 mL	9.6430 mL
20 mM	0.0964 mL	0.4822 mL	0.9643 mL	4.8215 mL
50 mM	0.0386 mL	0.1929 mL	0.3857 mL	1.9286 mL
100 mM	0.0193 mL	0.0964 mL	0.1929 mL	0.9643 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc