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Sulfinpyrazone

Name: Sulfinpyrazone
Brand: TargetMol
SKU: T0435
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0435Cas No. 57-96-5

Alias NSC 75925, G-28315, (+/-)-Sulfinpyrazone

Sulfinpyrazone (NSC-75925) is a uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.

Sulfinpyrazone

🥰Excellent

Purity: 99.52%

Catalog No. T0435Alias NSC 75925, G-28315, (+/-)-SulfinpyrazoneCas No. 57-96-5

Sulfinpyrazone (NSC-75925) is a uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.52%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Sulfinpyrazone (NSC-75925) is a uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.
In vivo	Sulfinpyrazone exerts significant electrophysiologic actions under various experimental conditions. It raises the ventricular fibrillation threshold as well as the mid diastolic threshold and prolongs the effective refractory period. In the acutely ischemic heart, it attenuates the effect of coronary occlusion on the ventricular fibrillation threshold but has no effect after reperfusion. A protective influence of the drug is also evident during sympathetic humoral stimulation with norepinephrine. The antifibrillatory effect of sulfinpyrazone is additive to the changes elicited by beta adrenergic blockade with practolol or cardiac membrane stabilization with lidocaine[1].
Synonyms	NSC 75925, G-28315, (+/-)-Sulfinpyrazone

Chemical Properties

Molecular Weight	404.48
Formula	C₂₃H₂₀N₂O₃S
Cas No.	57-96-5
Smiles	O=C1N(N(C(=O)C1CCS(=O)C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=CC=C4
Relative Density.	1.39 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 64 mg/mL (158.23 mM), Sonication is recommended.

DMSO: 40 mg/mL (98.89 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.94 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.4723 mL	12.3616 mL	24.7231 mL	123.6155 mL
5 mM	0.4945 mL	2.4723 mL	4.9446 mL	24.7231 mL
10 mM	0.2472 mL	1.2362 mL	2.4723 mL	12.3616 mL
20 mM	0.1236 mL	0.6181 mL	1.2362 mL	6.1808 mL
50 mM	0.0494 mL	0.2472 mL	0.4945 mL	2.4723 mL

Ethanol

	1mg	5mg	10mg	50mg
100 mM	0.0247 mL	0.1236 mL	0.2472 mL	1.2362 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc