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Anti-Phospho-Cbl-c (Tyr731) Polyclonal Antibody

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Catalog No. TMAC-00636

Anti-Phospho-Cbl-c (Tyr731) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Cbl-c (Tyr731). Anti-Phospho-Cbl-c (Tyr731) Polyclonal Antibody can be used in WB.

Anti-Phospho-Cbl-c (Tyr731) Polyclonal Antibody

Anti-Phospho-Cbl-c (Tyr731) Polyclonal Antibody

😃Good
Catalog No. TMAC-00636
Anti-Phospho-Cbl-c (Tyr731) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Cbl-c (Tyr731). Anti-Phospho-Cbl-c (Tyr731) Polyclonal Antibody can be used in WB.
Pack SizePriceAvailabilityQuantity
50 μL$2167-10 days
100 μL$3187-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-Cbl-c (Tyr731) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Cbl-c (Tyr731). Anti-Phospho-Cbl-c (Tyr731) Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human
Application
Recommended Dose
WB: 1:1000-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
ConstructionPolyclonal Antibody
PurificationThe antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
AppearanceLiquid
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Research BackgroundCbl proto-oncogene(CBL) Homo sapiens This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016],
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
A synthesized phosphopeptide: human c-Cbl around the phosphorylation site of Tyr731
Antigen Species
human
Uniprot ID
Chemical Properties
Molecular WeightActual: 100 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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