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IL12RB2 Protein, Human, Recombinant (HEK293, His)
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Catalog No. TMPY-07002 Copy Product Info
IL12RB2 Protein, Human, Recombinant (HEK293, His) is expressed in HEK293 Cells. The accession number is Q99665-2.
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $77 | 7-10 days | 7-10 days | |
| 10 µg | $126 | 7-10 days | 7-10 days | |
| 20 µg | $198 | 7-10 days | 7-10 days | |
| 50 µg | $397 | 7-10 days | 7-10 days | |
| 100 µg | $796 | 7-10 days | 7-10 days | |
| 200 µg | $1,200 | 7-10 days | 7-10 days | |
| 500 µg | $2,590 | 7-10 days | 7-10 days | |
| 1 mg | $5,280 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Immobilized IL-12 Protein, Human, Recombinant (Cat#TMPY-04863) at 2 μg/mL (100 μl/well) can bind IL12RB2 Protein, Human, Recombinant (HEK293, His) (Cat#TMPY-07002H), the EC50 is 20-90 ng/mL. |
| Description | IL12RB2 Protein, Human, Recombinant (HEK293, His) is expressed in HEK293 Cells. The accession number is Q99665-2. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-His |
| Accession Number | Q99665-2 |
| Construction | A DNA sequence encoding the Human IL12RB2 (NP_001245143.1) (Lys24-Asn622) was expressed with a polyhistidine tag at the C-terminus. |
| Protein Purity | ≥ 90% as determined by SDS-PAGE. ≥ 95% as determined by SEC-HPLC. |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Reconstitution | Please refer to the lot-specific COA. |
| Research Background | Interleukin-12 receptor subunit beta-2 (IL12RB2), also known as IL-12 receptor subunit beta-2, IL-12R subunit beta-2, IL-12R-beta-2, and IL-12RB2, is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. IL12RB2 belongs to the type I cytokine receptor family. The coexpression of IL12RB2 and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of IL12RB2 is up-regulated by IFN gamma in Th1 cells and plays a role in Th1 cell differentiation. The up-regulation of IL12RB2 is found to be associated with some infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. IL12RB2 promotes the proliferation of T-cells as well as NK cells. IL12RB2 induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. |
| Molecular Weight | 69.49 kDa (predicted); 88.1 kDa (reducing contition, due to glycosylation) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: IL12RB2 Protein, Human, Recombinant (HEK293, His) chemical structure | IL12RB2 Protein, Human, Recombinant (HEK293, His) molecular weight
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