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CM-352

Name: CM-352
Brand: TargetMol
SKU: T70470
Price: 416 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T70470Cas No. 1542205-83-3

CM-352 is a metalloproteinase inhibitor that reduces brain damage and improves functional recovery in rat models of cerebral hemorrhage.

CM-352

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Purity: 97.24%

Catalog No. T70470Cas No. 1542205-83-3

CM-352 is a metalloproteinase inhibitor that reduces brain damage and improves functional recovery in rat models of cerebral hemorrhage.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$416	In Stock	In Stock
5 mg	$882	In Stock	In Stock
10 mg	$1,080	In Stock	In Stock
25 mg	$1,420	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.24%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR ORP LCMS

Product Introduction

CM-352 AI Summary

CM-352 exhibits a range of bioactivities. It demonstrates antifibrinolytic activity in human whole blood by delaying clot lysis after 60 minutes, with an EC50 of 0.7 nM. It inhibits MMP-10 and MMP-3 with IC50 values of 12.0 nM and 15.0 nM, respectively. The compound inhibits various human liver microsomal CYP enzymes (1A2, 2C9, 2C19, 2D6, 3A4) with inhibition rates ranging from 9.4% to 43.7% at 10 μM. It also shows high metabolic stability in human, mouse, and rat liver microsomes, with stability percentages from 93.5% to 98.1%. The compound does not significantly inhibit the human ERG channel, with an IC50 above 100000.0 nM. In a C57BL6 mouse bleeding model, it reduces tPA-induced bleeding time at 1 mg/kg/hr, with a measured time of 0.03033 hr. CM-352 shows low permeability in human Caco2 cells and has an efflux ratio of 2.6. Additionally, it exhibits relatively good kinetic solubility at 200 μM at pH 7.4, with a solubility of 103.25 μg/mL..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	CM-352 is a metalloproteinase inhibitor that reduces brain damage and improves functional recovery in rat models of cerebral hemorrhage.
Targets&IC50	MMP10:12 nM, MMP3:15 nM

Chemical Properties

Molecular Weight	487.57
Formula	C₂₄H₂₉N₃O₆S
Cas No.	1542205-83-3
Smiles	S(=O)(=O)([C@@]1(C(NO)=O)CC2(CC1)CCNCC2)C3=CC=C(OC4=CC=C(C(NC)=O)C=C4)C=C3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 18.33 mg/mL (37.59 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0510 mL	10.2549 mL	20.5099 mL	102.5494 mL
5 mM	0.4102 mL	2.0510 mL	4.1020 mL	20.5099 mL
10 mM	0.2051 mL	1.0255 mL	2.0510 mL	10.2549 mL
20 mM	0.1025 mL	0.5127 mL	1.0255 mL	5.1275 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc