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ML-354

Name: ML-354
Brand: TargetMol
SKU: T21901
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21901Cas No. 89159-60-4

Alias VU0099704, VU 0099704, ML354

ML-354 (VU0099704) is a selective and potent PAR4 antagonist for the study of cardiovascular disease.

ML-354

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Purity: 99.44%

Catalog No. T21901Alias VU0099704, VU 0099704, ML354Cas No. 89159-60-4

ML-354 (VU0099704) is a selective and potent PAR4 antagonist for the study of cardiovascular disease.

Pack Size	Price	Availability
1 mg	$50	In Stock
5 mg	$113	In Stock
10 mg	$197	In Stock
25 mg	$462	In Stock
50 mg	$669	In Stock
100 mg	$943	In Stock
200 mg	$1,270	In Stock

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Batch Information

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Purity:99.44%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	ML-354 (VU0099704) is a selective and potent PAR4 antagonist for the study of cardiovascular disease.
Targets&IC50	PAR4 receptor:140 nM
In vitro	ML-354 is a specific PAR4 receptor antagonist with an IC50 value of 140 nM. [1]
Synonyms	VU0099704, VU 0099704, ML354

Chemical Properties

Molecular Weight	282.29
Formula	C₁₆H₁₄N₂O₃
Cas No.	89159-60-4
Smiles	CN1C(CO)=C(C2=CC=CC=C2)C3=C1C=CC([N+]([O-])=O)=C3
Relative Density.	1.29g/cm3
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (70.85 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5425 mL	17.7123 mL	35.4246 mL	177.1228 mL
5 mM	0.7085 mL	3.5425 mL	7.0849 mL	35.4246 mL
10 mM	0.3542 mL	1.7712 mL	3.5425 mL	17.7123 mL
20 mM	0.1771 mL	0.8856 mL	1.7712 mL	8.8561 mL
50 mM	0.0708 mL	0.3542 mL	0.7085 mL	3.5425 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc