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Bcl-xL antagonist 2

🥰Excellent
Catalog No. T38622Cas No. 1235032-75-3

Bcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of 91 nM and a Ki of 65 nM. Bcl-xL antagonist 2 induces apoptosis in cancer cells and can be used in studies about chronic lymphocytic leukemia and non-Hodgkin's lymphoma.

Bcl-xL antagonist 2

Bcl-xL antagonist 2

🥰Excellent
Purity: 99.81%
Catalog No. T38622Cas No. 1235032-75-3
Bcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of 91 nM and a Ki of 65 nM. Bcl-xL antagonist 2 induces apoptosis in cancer cells and can be used in studies about chronic lymphocytic leukemia and non-Hodgkin's lymphoma.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$74In StockIn Stock
5 mg$178In StockIn Stock
10 mg$275In StockIn Stock
25 mg$496In StockIn Stock
50 mg$690In StockIn Stock
100 mg$888In StockIn Stock
200 mg$1,190-In Stock
1 mL x 10 mM (in DMSO)$202In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.81%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
Bcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of 91 nM and a Ki of 65 nM. Bcl-xL antagonist 2 induces apoptosis in cancer cells and can be used in studies about chronic lymphocytic leukemia and non-Hodgkin's lymphoma.
Targets&IC50
BCL-XL:0.091 μM
In vivo
Bcl-xL antagonist 2 (1 mg/kg;i.v.) exhibits good PK profile with CL, Vss, t1/2 and F of 0.47 mL/min/kg, 0.16 L/kg, 6.0 h and 16% in rats[1].
Chemical Properties
Molecular Weight436.51
FormulaC21H16N4O3S2
Cas No.1235032-75-3
SmilesOC(=O)c1csc(n1)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (114.54 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2909 mL11.4545 mL22.9090 mL114.5449 mL
5 mM0.4582 mL2.2909 mL4.5818 mL22.9090 mL
10 mM0.2291 mL1.1454 mL2.2909 mL11.4545 mL
20 mM0.1145 mL0.5727 mL1.1454 mL5.7272 mL
50 mM0.0458 mL0.2291 mL0.4582 mL2.2909 mL
100 mM0.0229 mL0.1145 mL0.2291 mL1.1454 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

Bcl-xL antagonist 2BclxL antagonist 2Bcl-xLBcl xL antagonist 2
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