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WAY-213613 hydrochloride

Name: WAY-213613 hydrochloride
Brand: TargetMol
SKU: T13330
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13330Cas No. 2450268-84-3

Alias WAY-213613 hydrochloride (868359-05-1 free base)

WAY-213613 hydrochloride is a potent, selective nonsubstrate reuptake inhibitor of GLT-1/EAAT2 with IC 50 of 85 nM. WAY-213613 hydrochloride inhibits EAAT1 and EAAT3 with IC50 values of 5 and 3.8 microM, respectively. WAY-213613 hydrochloride shows no activity at ionotropic and metabotropic glutamate receptors. It is a potential tool for the elucidation of EAAT2 function and can be used for the research of central nervous system [1] [2].

WAY-213613 hydrochloride

🥰Excellent

Purity: 99.37%

Catalog No. T13330Alias WAY-213613 hydrochloride (868359-05-1 free base)Cas No. 2450268-84-3

Pack Size	Price	Availability
1 mg	$32	In Stock
5 mg	$77	In Stock
10 mg	$98	In Stock
25 mg	$238	In Stock
50 mg	$398	In Stock
100 mg	$678	In Stock
200 mg	$918	In Stock
1 mL x 10 mM (in DMSO)	$86	In Stock

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Purity:99.37%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	WAY-213613 hydrochloride is a potent, selective nonsubstrate reuptake inhibitor of GLT-1/EAAT2 with IC 50 of 85 nM. WAY-213613 hydrochloride inhibits EAAT1 and EAAT3 with IC50 values of 5 and 3.8 microM, respectively. WAY-213613 hydrochloride shows no activity at ionotropic and metabotropic glutamate receptors. It is a potential tool for the elucidation of EAAT2 function and can be used for the research of central nervous system [1] [2].
Targets&IC50	EAAT3 (human):3.8 μM , EAAT1 (human):5 μM , EAAT2 (human):85 nM
Synonyms	WAY-213613 hydrochloride (868359-05-1 free base)

Chemical Properties

Molecular Weight	415.19
Formula	C₁₆H₁₃BrF₂N₂O₄
Cas No.	2450268-84-3
Smiles	N[C@@H](CC(Nc(cc1)ccc1Oc(cc(c(F)c1)F)c1Br)=O)C(O)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 55 mg/mL (121.78 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4085 mL	12.0427 mL	24.0854 mL	120.4268 mL
5 mM	0.4817 mL	2.4085 mL	4.8171 mL	24.0854 mL
10 mM	0.2409 mL	1.2043 mL	2.4085 mL	12.0427 mL
20 mM	0.1204 mL	0.6021 mL	1.2043 mL	6.0213 mL
50 mM	0.0482 mL	0.2409 mL	0.4817 mL	2.4085 mL
100 mM	0.0241 mL	0.1204 mL	0.2409 mL	1.2043 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc