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WAY-213613 hydrochloride

Name: WAY-213613 hydrochloride
Brand: TargetMol
SKU: T13330
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13330Cas No. 2450268-84-3

Alias WAY-213613 hydrochloride (868359-05-1 free base)

WAY-213613 hydrochloride is a potent, selective nonsubstrate reuptake inhibitor of GLT-1/EAAT2 with IC 50 of 85 nM. WAY-213613 hydrochloride inhibits EAAT1 and EAAT3 with IC50 values of 5 and 3.8 microM, respectively. WAY-213613 hydrochloride shows no activity at ionotropic and metabotropic glutamate receptors. It is a potential tool for the elucidation of EAAT2 function and can be used for the research of central nervous system [1] [2].

WAY-213613 hydrochloride

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Purity: 99.37%

Catalog No. T13330Alias WAY-213613 hydrochloride (868359-05-1 free base)Cas No. 2450268-84-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	In Stock	In Stock
5 mg	$77	In Stock	In Stock
10 mg	$98	In Stock	In Stock
25 mg	$238	In Stock	In Stock
50 mg	$398	In Stock	In Stock
100 mg	$678	In Stock	In Stock
200 mg	$918	-	In Stock
1 mL x 10 mM (in DMSO)	$86	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.37%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	WAY-213613 hydrochloride is a potent, selective nonsubstrate reuptake inhibitor of GLT-1/EAAT2 with IC 50 of 85 nM. WAY-213613 hydrochloride inhibits EAAT1 and EAAT3 with IC50 values of 5 and 3.8 microM, respectively. WAY-213613 hydrochloride shows no activity at ionotropic and metabotropic glutamate receptors. It is a potential tool for the elucidation of EAAT2 function and can be used for the research of central nervous system [1] [2].
Targets&IC50	EAAT1 (human):5 μM , EAAT2 (human):85 nM , EAAT3 (human):3.8 μM
Synonyms	WAY-213613 hydrochloride (868359-05-1 free base)

Chemical Properties

Molecular Weight	415.19
Formula	C₁₆H₁₃BrF₂N₂O₄
Cas No.	2450268-84-3
Smiles	N[C@@H](CC(Nc(cc1)ccc1Oc(cc(c(F)c1)F)c1Br)=O)C(O)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 55 mg/mL (132.47 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4085 mL	12.0427 mL	24.0854 mL	120.4268 mL
5 mM	0.4817 mL	2.4085 mL	4.8171 mL	24.0854 mL
10 mM	0.2409 mL	1.2043 mL	2.4085 mL	12.0427 mL
20 mM	0.1204 mL	0.6021 mL	1.2043 mL	6.0213 mL
50 mM	0.0482 mL	0.2409 mL	0.4817 mL	2.4085 mL
100 mM	0.0241 mL	0.1204 mL	0.2409 mL	1.2043 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc