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TEAD1/3/4-IN-1

🥰Excellent
Catalog No. T207812Cas No. 2762619-63-4

TEAD1/3/4-IN-1 (compound 1) is an inhibitor of TEAD1/3/4 that suppresses YAP/TAZ-TEAD interactions. It exhibits antitumour activity against NF2-deficient NCI-H226 cells and may be employed in studies of cancer and diseases mediated by Hippo pathway abnormalities.

TEAD1/3/4-IN-1

TEAD1/3/4-IN-1

🥰Excellent
Purity: 99.25%
Catalog No. T207812Cas No. 2762619-63-4
TEAD1/3/4-IN-1 (compound 1) is an inhibitor of TEAD1/3/4 that suppresses YAP/TAZ-TEAD interactions. It exhibits antitumour activity against NF2-deficient NCI-H226 cells and may be employed in studies of cancer and diseases mediated by Hippo pathway abnormalities.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$50-In Stock
5 mg$118-In Stock
10 mg$189-In Stock
25 mg$385-In Stock
50 mg$579-In Stock
100 mg$868-In Stock
200 mg$1,170-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.25%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
TEAD1/3/4-IN-1 (compound 1) is an inhibitor of TEAD1/3/4 that suppresses YAP/TAZ-TEAD interactions. It exhibits antitumour activity against NF2-deficient NCI-H226 cells and may be employed in studies of cancer and diseases mediated by Hippo pathway abnormalities.
Chemical Properties
Molecular Weight407.32
FormulaC18H13F4N5O2
Cas No.2762619-63-4
SmilesO=C(C(F)=C)N1CC(N2C(=O)N(C3=CC=C(C=C3)C(F)(F)F)C4=NC=CN=C42)C1
Relative Density.no data available
ColorYellow
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 20 mg/mL (49.1 mM)
In Vivo Formulation
10% DMSO+90% Corn Oil: 2 mg/mL (4.91 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4551 mL12.2754 mL24.5507 mL122.7536 mL
5 mM0.4910 mL2.4551 mL4.9101 mL24.5507 mL
10 mM0.2455 mL1.2275 mL2.4551 mL12.2754 mL
20 mM0.1228 mL0.6138 mL1.2275 mL6.1377 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TEAD1/3/4IN1
Related Tags: buy TEAD1/3/4-IN-1 | purchase TEAD1/3/4-IN-1 | TEAD1/3/4-IN-1 cost | order TEAD1/3/4-IN-1 | TEAD1/3/4-IN-1 chemical structure | TEAD1/3/4-IN-1 formula | TEAD1/3/4-IN-1 molecular weight
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