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NP-313

Name: NP-313
Brand: TargetMol
SKU: T24542
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24542Cas No. 5397-78-4

Alias NSC-4264, NSC4264, NSC 4264, NP 313

NP-313 (NSC-4264) is a potent antithrombotic agent that inhibits platelet aggregation and activation by inhibiting thromboxane A 2 synthesis and selectively inhibiting SOCC-mediated Ca2+ efflux.

NP-313

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Purity: 99.92%

Catalog No. T24542Alias NSC-4264, NSC4264, NSC 4264, NP 313Cas No. 5397-78-4

NP-313 (NSC-4264) is a potent antithrombotic agent that inhibits platelet aggregation and activation by inhibiting thromboxane A 2 synthesis and selectively inhibiting SOCC-mediated Ca2+ efflux.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
5 mg	$122	In Stock	In Stock
10 mg	$197	In Stock	In Stock
25 mg	$397	In Stock	In Stock
50 mg	$589	In Stock	In Stock
100 mg	$843	In Stock	In Stock
500 mg	$1,730	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.92%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	NP-313 (NSC-4264) is a potent antithrombotic agent that inhibits platelet aggregation and activation by inhibiting thromboxane A 2 synthesis and selectively inhibiting SOCC-mediated Ca2+ efflux.
Targets&IC50	COX-1:1.5 µM, TXA2:3.9 µM
In vitro	NP-313 (0-80 μM) inhibits platelet aggregation in a dose-dependent manner, reducing thrombin- and A23187-induced aggregation by up to 80% and 60%, respectively.[1] At concentrations of 0-8 μM, NP-313 concentration-dependently inhibits P-selectin expression and collagen- or thrombin-induced thromboxane B2 (TXB2) production in human platelets, and inhibits COX-1 and TXA2 synthase with IC50 values of 1.5 and 3.9 μM, respectively.[1]
In vivo	NP-313 (4-16 µg/g; i.v.) significantly prolongs time-to-occlusion (TTO), prolongs bleeding time, and inhibits platelet aggregation induced by collagen (10 µg/mL) in male ICR mice.[1]
Synonyms	NSC-4264, NSC4264, NSC 4264, NP 313

Chemical Properties

Molecular Weight	249.65
Formula	C₁₂H₈ClNO₃
Cas No.	5397-78-4
Smiles	O=C1C=2C(C(=O)C(Cl)=C1NC(C)=O)=CC=CC2
Relative Density.	1.44g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (240.34 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0056 mL	20.0280 mL	40.0561 mL	200.2804 mL
5 mM	0.8011 mL	4.0056 mL	8.0112 mL	40.0561 mL
10 mM	0.4006 mL	2.0028 mL	4.0056 mL	20.0280 mL
20 mM	0.2003 mL	1.0014 mL	2.0028 mL	10.0140 mL
50 mM	0.0801 mL	0.4006 mL	0.8011 mL	4.0056 mL
100 mM	0.0401 mL	0.2003 mL	0.4006 mL	2.0028 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc