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Bromisoval

Name: Bromisoval
Brand: TargetMol
SKU: T0227
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0227Cas No. 496-67-3

Alias Isobromyl, Bromovalerylurea, Bromaral, BRN 1773255, 2-Bromo-N-carbamoyl-3-methylbutanamide

Bromisoval (Isobromyl) is a mild hypnotic and sedative with potential toxicity.

Bromisoval

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Purity: 98.86%

Catalog No. T0227Alias Isobromyl, Bromovalerylurea, Bromaral, BRN 1773255, 2-Bromo-N-carbamoyl-3-methylbutanamideCas No. 496-67-3

Bromisoval (Isobromyl) is a mild hypnotic and sedative with potential toxicity.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$29	In Stock	-
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.86%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bromisoval AI Summary

Bromisoval shows promising bioactivities across multiple biological targets and pathways. This compound modulates Lamin A splicing, influences Schwann cell PMP22 intronic element activity as demonstrated with firefly luciferase assays, identifies small molecules targeting β-Galactocerebrosidase, and blocks Ebola virus entry in various screening channels. It has been shown to produce potent yet varying effects across different assays, indicating its potential as a multi-target therapeutic. Additionally, in DrugMatrix assays with a daily repeat regimen, Bromisoval has demonstrated significant effects on liver and kidney function, glucose and cholesterol levels, various enzyme and electrolyte levels, as well as detailed blood cell counts and differential cell counts, providing comprehensive insights into its systemic impacts. Furthermore, the compound exhibits moderate antiviral activity against SARS-CoV-2 with an IC50 value above 20,000 nM, showing potential in inhibiting virus-induced cytotoxicity in VERO-6 cells. Interpretation of these results should be conducted by qualified researchers or medical professionals given the complexity and breadth of its bioactive profile..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Bromisoval (Isobromyl) is a mild hypnotic and sedative with potential toxicity.
Synonyms	Isobromyl, Bromovalerylurea, Bromaral, BRN 1773255, 2-Bromo-N-carbamoyl-3-methylbutanamide

Chemical Properties

Molecular Weight	223.07
Formula	C₆H₁₁BrN₂O₂
Cas No.	496-67-3
Smiles	C(C(C(C)C)Br)(NC(N)=O)=O
Relative Density.	1.504g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (179.32 mM), Sonication is recommended.

Ethanol: Soluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (22.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4829 mL	22.4145 mL	44.8290 mL	224.1449 mL
5 mM	0.8966 mL	4.4829 mL	8.9658 mL	44.8290 mL
10 mM	0.4483 mL	2.2414 mL	4.4829 mL	22.4145 mL
20 mM	0.2241 mL	1.1207 mL	2.2414 mL	11.2072 mL
50 mM	0.0897 mL	0.4483 mL	0.8966 mL	4.4829 mL
100 mM	0.0448 mL	0.2241 mL	0.4483 mL	2.2414 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc