Contezolid acefosamil sodium

Name: Contezolid acefosamil sodium
Brand: TargetMol
SKU: T36441
Rating: 4.5 (1 reviews)

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Catalog No. T36441Cas No. 1807365-35-0

Contezolid acefosamil sodium (MRX-4) is a novel orally active oxazolidinone antibiotic under investigation for the treatment of complicated skin and soft tissue infections (cSSTI) caused by drug-resistant Gram-positive bacteria. It possesses strong efficacy against these pathogens while significantly minimizing the risks of myelosuppression and monoamine oxidase inhibition (MAOI) [1][2].

Contezolid acefosamil sodium

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Catalog No. T36441Cas No. 1807365-35-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$764	Inquiry	Inquiry
10 mg	$1,190	Inquiry	Inquiry

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Contezolid acefosamil sodium (MRX-4) is a novel orally active oxazolidinone antibiotic under investigation for the treatment of complicated skin and soft tissue infections (cSSTI) caused by drug-resistant Gram-positive bacteria. It possesses strong efficacy against these pathogens while significantly minimizing the risks of myelosuppression and monoamine oxidase inhibition (MAOI) [1][2].
In vitro	Contezolid (MRX-I) demonstrates strong efficacy against a broad spectrum of Gram-positive clinical isolates, including staphylococci, streptococci, and enterococci. Its potency extends to multidrug-resistant (MDR) organisms, such as MRSA, methicillin-resistant Streptococcus epidermidis (MRSE), penicillin-resistant Streptococci (PRSP), and vancomycin-resistant enterococci (VRE)[2].
In vivo	Oral absorption of Contezolid (MRX-I) occurs rapidly in mouse, rat, and dog, with peak plasma concentrations at 0.5-2.6 h postdose. In these species respectively, dose-normalized Cmax/dose was 524, 1065, and 259 ng/mL/(mg/kg); dose-normalized AUC0-t/dose was 1654, 3703, and 1664 ng·h/mL/(mg/kg); T1/2 is 1, 1.5, and 3 h; and oral bioavailability is 69%, 109%, and 37%[2]. Contezolid (MRX-I) shows no obvious toxicity [2]. Contezolid (MRX-I, 100 mg/kg, once daily) significantly reduced the bacterial load in lungs compared to untreated controls[3].

Chemical Properties

Molecular Weight	552.33
Formula	C₂₀H₁₇F₃N₄NaO₈P
Cas No.	1807365-35-0
Smiles	CC(OP([O-])(N(c1nocc1)C[C@H]2CN(c3c(F)c(F)c(N4CCC(C=C4)=O)c(F)c3)C(O2)=O)=O)=O.[Na+]

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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