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Anti-PRTFDC1 Antibody (6G114) is a Mouse antibody targeting PRTFDC1. Anti-PRTFDC1 Antibody (6G114) can be used in WB,ELISA.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 μL | $199 | 7-10 days |
Description | Anti-PRTFDC1 Antibody (6G114) is a Mouse antibody targeting PRTFDC1. Anti-PRTFDC1 Antibody (6G114) can be used in WB,ELISA. |
Alias | PRTFDC1, phosphoribosyl transferase domain containing 1, HHGP |
Ig Type | Monoclonal Mouse IgG1 |
Clone | 6G114 |
Reactivity | Human |
Verified Activity | Anti-PRTFDC1 mouse monoclonal antibody at 1:500 dilution. -Lane A: 293T Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Mouse IgG H&L (Dylight800) at 1/15000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:28 kDa. -Observed band size:28 kDa |
Application | WB,ELISA |
Recommended Dose | WB: 1:500-1:1000; ELISA: 1:5000-1:10000 |
Antibody Type | Monoclonal |
Host Species | Mouse |
Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human PRTFDC1 (rh PRTFDC1; TMPY-03332; Q9NRG1-1; Met1-Val225). The IgG fraction of the cell culture supernatant was purified by Protein A affinity. |
Purification | Protein A |
Appearance | Liquid |
Formulation | 0.2 μm filtered solution in PBS |
Research Background | PRTFDC1 is a member of the purine/pyrimidine phosphoribosyltransferase family. It can bind GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). The epigenetic silencing of PRTFDC1 by hypermethylation of the CpG island leads to a loss of PRTFDC1 function, which might be involved in squamous cell oral carcinogenesis. PRTFDC1 is a genetic modifier of HPRT-deficiency in the mouse and has important implications for unraveling the molecular etiology of lesch-Nyhan disease(LND). LND is a severe X-linked neurological disorder caused by a deficiency of hypoxanthine phosphoribosyltransferase. PRTFDC1 has a low, barely measurable phosphoribosyltransferase activity (in vitro). |
Conjucates | Unconjugated |
Immunogen | Recombinant Human PRTFDC1 protein (TMPY-03332) |
Antigen Species | Human |
Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
Transport | Shipping with blue ice. |
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