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Praliciguat

Name: Praliciguat
Brand: TargetMol
SKU: T16569
Price: 153 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16569Cas No. 1628730-49-3

Alias IW-1973

Praliciguat (IW-1973) stimulates sGC in HEK-293 cells (EC50: 197 nM). Praliciguat is an effective and orally active soluble guanylate cyclase stimulator. It also enhances NO signaling and acts as a vasodilator.

Praliciguat

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Purity: 98.82%

Catalog No. T16569Alias IW-1973Cas No. 1628730-49-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$153	In Stock	In Stock
2 mg	$229	In Stock	In Stock
5 mg	$387	In Stock	In Stock
10 mg	$597	In Stock	In Stock
25 mg	$953	In Stock	In Stock
50 mg	$1,290	-	In Stock
100 mg	$1,730	-	In Stock
1 mL x 10 mM (in DMSO)	$455	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.82%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Praliciguat AI Summary

Praliciguat has a half-life of 24.0 hours in human subjects..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Praliciguat (IW-1973) stimulates sGC in HEK-293 cells (EC50: 197 nM). Praliciguat is an effective and orally active soluble guanylate cyclase stimulator. It also enhances NO signaling and acts as a vasodilator.
Targets&IC50	sGC:（EC50）197 nM
Synonyms	IW-1973

Chemical Properties

Molecular Weight	534.36
Formula	C₂₁H₁₄F₈N₆O₂
Cas No.	1628730-49-3
Smiles	OC(CNc1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1)(C(F)(F)F)C(F)(F)F
Relative Density.	1.60 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 245 mg/mL (458.49 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (9.36 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8714 mL	9.3570 mL	18.7140 mL	93.5699 mL
5 mM	0.3743 mL	1.8714 mL	3.7428 mL	18.7140 mL
10 mM	0.1871 mL	0.9357 mL	1.8714 mL	9.3570 mL
20 mM	0.0936 mL	0.4678 mL	0.9357 mL	4.6785 mL
50 mM	0.0374 mL	0.1871 mL	0.3743 mL	1.8714 mL
100 mM	0.0187 mL	0.0936 mL	0.1871 mL	0.9357 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc