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CD30/TNFRSF8 Protein, Human, Recombinant (aa 19-379, His)

Catalog No. TMPJ-00342
Synonyms: Lymphocyte activation antigen CD30, TNFRSF8, Tumor necrosis factor receptor superfamily member 8, Ki-1 antigen, CD30L receptor, CD30

CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family, which regulates proliferation/apoptosis and antibody responses. CD30 is expressed by activated, but not by resting, T and B cells. Aberrant expression of CD30 by mastocytosis mast cells and interaction with its ligand CD30L (CD153) appears to play an important role in the pathogenesis and clinical presentation of systemic mastocytosis. CD30 has been considered as a specific diagnostic biomarker of anaplastic large cell lymphoma (ALCL) and classical Hodgkin lymphoma (cHL). CD30 is also a biomarker used for targeted therapy by an antibody–drug conjugate.

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CD30/TNFRSF8 Protein, Human, Recombinant (aa 19-379, His)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 110.00
50 μg 5 days $ 310.00
500 μg 5 days $ 1,570.00
1 mg 5 days $ 2,230.00
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Biological Description
Technical Params
Product Properties
Description CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family, which regulates proliferation/apoptosis and antibody responses. CD30 is expressed by activated, but not by resting, T and B cells. Aberrant expression of CD30 by mastocytosis mast cells and interaction with its ligand CD30L (CD153) appears to play an important role in the pathogenesis and clinical presentation of systemic mastocytosis. CD30 has been considered as a specific diagnostic biomarker of anaplastic large cell lymphoma (ALCL) and classical Hodgkin lymphoma (cHL). CD30 is also a biomarker used for targeted therapy by an antibody–drug conjugate.
Species Human
Expression System Human Cells
Tag C-6His
Accession Number P28908
Synonyms Lymphocyte activation antigen CD30, TNFRSF8, Tumor necrosis factor receptor superfamily member 8, Ki-1 antigen, CD30L receptor, CD30
Amino Acid Phe19-Lys379
Construction Recombinant Human CD30 is produced by our Mammalian expression system and the target gene encoding Phe19-Lys379 is expressed with a 6His tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 60-95 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 7.5 .
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.

Research Background CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family, which regulates proliferation/apoptosis and antibody responses. CD30 is expressed by activated, but not by resting, T and B cells. Aberrant expression of CD30 by mastocytosis mast cells and interaction with its ligand CD30L (CD153) appears to play an important role in the pathogenesis and clinical presentation of systemic mastocytosis. CD30 has been considered as a specific diagnostic biomarker of anaplastic large cell lymphoma (ALCL) and classical Hodgkin lymphoma (cHL). CD30 is also a biomarker used for targeted therapy by an antibody–drug conjugate.

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Keywords

CD30/TNFRSF8 Protein, Human, Recombinant (aa 19-379, His) Lymphocyte activation antigen CD30 CD 30 TNFRSF8 Tumor necrosis factor receptor superfamily member 8 TNFRSF-8 Ki-1 antigen TNFRSF 8 CD30L receptor CD-30 CD30 recombinant recombinant-proteins proteins protein

 

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