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Fluconazole

Name: Fluconazole
Brand: TargetMol
SKU: T1388
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: UK-49858) Copy Product Info

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Synonyms: UK-49858

Catalog No. T1388 Copy Product Info

Purity: 99.17%

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Fluconazole (UK-49858) belongs to the triazole class of antifungal agents and is a CYP51 inhibitor (IC99 = 0.20–0.39 μg/mL against Candida albicans), possessing broad-spectrum antifungal activity, good oral absorption, and cell permeability. This compound is used for the treatment of various invasive fungal infections.

Cas No. 86386-73-4

Pack Size	Price	USA Stock	Global Stock
50 mg	$36	In Stock	In Stock
100 mg	$48	In Stock	In Stock
200 mg	$59	In Stock	In Stock
500 mg	$72	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.17%

Appearance:Solid

Color:White

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	Fluconazole (UK-49858) belongs to the triazole class of antifungal agents and is a CYP51 inhibitor (IC99 = 0.20–0.39 μg/mL against Candida albicans), possessing broad-spectrum antifungal activity, good oral absorption, and cell permeability. This compound is used for the treatment of various invasive fungal infections.
In vitro	Methods: The in vitro antifungal activity of Fluconazole against clinically isolated Candida species was determined by CLSI M27-E4 broth microdilution method, with incubation for 24-48 hours. Results: The MIC90 of Fluconazole against Candida albicans was 2 μg/mL, with a susceptibility rate of 92%; against Candida glabrata, the MIC90 was 16 μg/mL, with 98% showing dose-dependent susceptibility. The wild-type proportion of Fluconazole for recurrent VVC strains was significantly lower than other types (67% vs 77%).[1] Methods: Broth microdilution method was used to determine the in vitro activity of Fluconazole against Candida. YPD medium was used, with Fluconazole concentrations ranging from 0-128 μg/mL (two-fold dilutions), inoculation of 2×10^5 CFU/mL Candida, and incubation at 30°C for 24 hours before MIC reading. Results: Fluconazole showed good inhibitory effects against susceptible strains, but MIC values were significantly elevated against resistant strains.[2]
In vivo	Methods: A Galleria mellonella larval systemic infection model with Candida albicans was established. Fluconazole (20 μg/mL, 10 μL per larva, dissolved in DMSO) was administered by single injection 1.5-2 hours post-infection. Results: Fluconazole monotherapy significantly prolonged the median survival time of infected larvae (9.33 days vs 2.33 days) and reduced fungal burden.[2]
Synonyms	UK-49858

Chemical Properties

Molecular Weight	306.27
Formula	C₁₃H₁₂F₂N₆O
Cas No.	86386-73-4
Smiles	FC1=CC=C(C(F)=C1)C(O)(CN2N=CN=C2)CN3N=CN=C3
Relative Density.	1.49 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 30.6 mg/mL (99.91 mM), Sonication is recommended.

DMSO: 260 mg/mL (848.92 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.53 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2651 mL	16.3255 mL	32.6509 mL	163.2546 mL
5 mM	0.6530 mL	3.2651 mL	6.5302 mL	32.6509 mL
10 mM	0.3265 mL	1.6325 mL	3.2651 mL	16.3255 mL
20 mM	0.1633 mL	0.8163 mL	1.6325 mL	8.1627 mL
50 mM	0.0653 mL	0.3265 mL	0.6530 mL	3.2651 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0327 mL	0.1633 mL	0.3265 mL	1.6325 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.