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CB1 inverse agonist 1

Name: CB1 inverse agonist 1
Brand: TargetMol
SKU: T10694
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T10694Cas No. 852315-00-5

Alias MRL-650

CB1 inverse agonist 1 (MRL-650) is an orally active and selective CB1 agonist. The IC50s for CB1 and CB2 are 7.5 nM and 4100 nM, respectively. CB1 inverse agonist 1 shows anorexigenic effects.

CB1 inverse agonist 1

🥰Excellent

Purity: 99.92%

Catalog No. T10694Alias MRL-650Cas No. 852315-00-5

CB1 inverse agonist 1 (MRL-650) is an orally active and selective CB1 agonist. The IC50s for CB1 and CB2 are 7.5 nM and 4100 nM, respectively. CB1 inverse agonist 1 shows anorexigenic effects.

Pack Size	Price	Availability
1 mg	$48	In Stock
5 mg	$113	In Stock
10 mg	$166	In Stock
25 mg	$248	In Stock
50 mg	$348	In Stock
100 mg	$475	In Stock
200 mg	$641	In Stock
1 mL x 10 mM (in DMSO)	$138	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.92%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	CB1 inverse agonist 1 (MRL-650) is an orally active and selective CB1 agonist. The IC50s for CB1 and CB2 are 7.5 nM and 4100 nM, respectively. CB1 inverse agonist 1 shows anorexigenic effects.
Targets&IC50	CB1:7.5 nM, CB2:4100 nM
In vivo	CB1 inverse agonist 1 (0.3-3 mg/kg) dose-dependently inhibits feeding in a manner[1].
Synonyms	MRL-650

Chemical Properties

Molecular Weight	514.79
Formula	C₂₅H₁₈Cl₃N₃O₃
Cas No.	852315-00-5
Smiles	N(C(C)=O)C=1C=2C(=NC(=C(C2)C3=CC=C(Cl)C=C3)C4=C(Cl)C=C(Cl)C=C4)N(C)C(=O)C1C(C)=O
Relative Density.	1.50 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (87.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9425 mL	9.7127 mL	19.4254 mL	97.1270 mL
5 mM	0.3885 mL	1.9425 mL	3.8851 mL	19.4254 mL
10 mM	0.1943 mL	0.9713 mL	1.9425 mL	9.7127 mL
20 mM	0.0971 mL	0.4856 mL	0.9713 mL	4.8563 mL
50 mM	0.0389 mL	0.1943 mL	0.3885 mL	1.9425 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc