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Anti-CD3 epsilon/CD3e Antibody (6O384) (Synonyms: CD3e molecule, ε (CD3-TCR complex), CD3e molecule, epsilon (C...)

Name: Anti-CD3 epsilon/CD3e Antibody (6O384)
Brand: TargetMol
SKU: TMAY-01395
Rating: 4.5 (1 reviews)

Catalog No. TMAY-01395 Copy Product Info

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Anti-CD3 epsilon/CD3e Antibody (6O384) is a Mouse antibody targeting CD3 epsilon/CD3e. Anti-CD3 epsilon/CD3e Antibody (6O384) can be used in FCM.

Anti-CD3 epsilon/CD3e Antibody (6O384)

Copy Product Info

🥰Excellent

Catalog No. TMAY-01395

Synonyms CD3e molecule, ε (CD3-TCR complex), CD3e molecule, epsilon (CD3-TCR complex), CD3 ε/CD3e

Anti-CD3 epsilon/CD3e Antibody (6O384) is a Mouse antibody targeting CD3 epsilon/CD3e. Anti-CD3 epsilon/CD3e Antibody (6O384) can be used in FCM.

Anti-CD3 epsilon/CD3e Antibody
(6O384)

Pack Size	Price	USA Stock	Global Stock	Quantity
20 μL	$92	7-10 days	7-10 days
100 μL	$270	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Anti-CD3 epsilon/CD3e Antibody (6O384) is a Mouse antibody targeting CD3 epsilon/CD3e. Anti-CD3 epsilon/CD3e Antibody (6O384) can be used in FCM.
Synonyms	CD3e molecule, ε (CD3-TCR complex), CD3e molecule, epsilon (CD3-TCR complex), CD3 ε/CD3e
Ig Type	Mouse IgG2a
Clone	6O384
Reactivity	Human
Specificity	Human CD3 epsilon/CD3e
Verified Activity	Flow cytometric analysis of Human CD3 expression on human peripheral blood lymphocytes. Cells were stained with purified Mouse anti-Human CD3, then a PE-conjugated second step antibody. The histogram were derived from events with the forward and side light-scatter characteristics of viable lymphocytes.
Application	FCM
Recommended Dose	FCM: 1:25-1:100
Antibody Type	Monoclonal
Host Species	Mouse
Construction	This product is a recombinant monoclonal antibody expressed from HEK293 cells.
Purification	Protein A
Appearance	Liquid
Formulation	0.2 μm filtered solution in PBS
Research Background	T-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. The CD3 epsilon subunit of the T cell receptor (TCR) complex contains two defined signaling domains, a proline-rich sequence and an immune tyrosine activation motifs (ITAMs), and this complex undergoes a conformational change upon ligand binding that is thought to be important for the activation of T cells. In the CD3 epsilon mutant mice, all stages of T cell development and activation that are TCR-dependent were impaired, but not eliminated, including activation of mature naïve T cells with the MHCII presented superantigen, staphylococcal enterotoxin B, or with a strong TCR cross-linking antibody specific for either TCR-Cbeta or CD3 epsilon. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. Homozygous mutations in CD3D and CD3E genes lead to a complete block in T-cell development and thus to an early-onset severe combined immunodeficiency phenotype.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

Related Conjugates and Formulations

Conjucates	Unconjugated
Others Formats	APC/PerCP/FITC/PE
Antibody Types Available	5

Antigen Details

Immunogen	Recombinant Protein: Human CD3e / CD3 epsilon protein (TMPY-01191)
Antigen Species	Human
Biology Area	ITIM/ITAM Immunoreceptors and Related Molecules

Chemical Properties

Stability & Storage

Stability & Storage	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
Transport	Shipping with blue ice.

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Keywords

CD3-TCR complexCD3e molecule, epsilon

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