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BAY-2402234

Name: BAY-2402234
Brand: TargetMol
SKU: T14501
Price: 183 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14501Cas No. 2225819-06-5

BAY-2402234 is an inhibitor of dihydroorotate dehydrogenase (DHODH) for the treatment of myeloid malignancies.BAY 2402234 is a selective low-nanomolar inhibitor of human DHODH enzymatic activity.

BAY-2402234

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Purity: 98.9%

Catalog No. T14501Cas No. 2225819-06-5

BAY-2402234 is an inhibitor of dihydroorotate dehydrogenase (DHODH) for the treatment of myeloid malignancies.BAY 2402234 is a selective low-nanomolar inhibitor of human DHODH enzymatic activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$183	In Stock	In Stock
2 mg	$259	In Stock	In Stock
5 mg	$387	In Stock	In Stock
10 mg	$597	In Stock	In Stock
25 mg	$953	In Stock	In Stock
50 mg	$1,290	In Stock	In Stock
100 mg	$1,730	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$446	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.9%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	BAY-2402234 is an inhibitor of dihydroorotate dehydrogenase (DHODH) for the treatment of myeloid malignancies.BAY 2402234 is a selective low-nanomolar inhibitor of human DHODH enzymatic activity.
In vitro	BAY-2402234 induces differentiation of AML cell lines also in a sub-nanomolar to low-nanomolar range which demonstrates the anticipated mode of action in cellular mechanistic assays[1]. BAY-2402234 is a selective low-nanomolar inhibitor of human DHODH enzymatic activity. It potently inhibits proliferation of AML cell lines in the sub-nanomolar to low-nanomolar range in vitro.
In vivo	BAY-2402234 demonstrates potent in vivo anti-tumor effectiveness as a single agent across various AML (acute myeloid leukemia) xenograft models, including subcutaneous, disseminated, and patient-derived (PDX) forms. It promotes AML cell differentiation, evident through increased differentiation cell surface markers in treated xenograft and PDX models. The engagement of this novel DHODH (dihydroorotate dehydrogenase) inhibitor is confirmed by elevated dihydroorotate levels in tumor tissues and plasma post-treatment. Additionally, transcriptomic analyses reveal differentiation-related changes after a single dose of BAY-2402234, underscoring its mechanistic impact on AML cells[1].

Chemical Properties

Molecular Weight	520.84
Formula	C₂₁H₁₈ClF₅N₄O₄
Cas No.	2225819-06-5
Smiles	CCn1c(CO)nn(-c2cc(O[C@@H](C)C(F)(F)F)c(cc2F)C(=O)Nc2c(F)cccc2Cl)c1=O
Relative Density.	1.52 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (288 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.68 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9200 mL	9.5999 mL	19.1998 mL	95.9988 mL
5 mM	0.3840 mL	1.9200 mL	3.8400 mL	19.1998 mL
10 mM	0.1920 mL	0.9600 mL	1.9200 mL	9.5999 mL
20 mM	0.0960 mL	0.4800 mL	0.9600 mL	4.7999 mL
50 mM	0.0384 mL	0.1920 mL	0.3840 mL	1.9200 mL
100 mM	0.0192 mL	0.0960 mL	0.1920 mL	0.9600 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc