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7-Amino-4-methylcoumarin-3-acetic acid

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Catalog No. TN1328Cas No. 106562-32-7

7-Amino-4-methylcoumarin-3-acetic acid [7-Amino-4-methylcoumarin] is a more suitable substrate for enteropeptidase compared to GD(4)K-NA.

7-Amino-4-methylcoumarin-3-acetic acid
Other Forms of 7-Amino-4-methylcoumarin-3-acetic acid:
7-Amino-4-methylcoumarin hydrogensulfateT85518207673-94-7
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7-Amino-4-methylcoumarin-3-acetic acid

🥰Excellent
Purity: 98.38%
Catalog No. TN1328Cas No. 106562-32-7
7-Amino-4-methylcoumarin-3-acetic acid [7-Amino-4-methylcoumarin] is a more suitable substrate for enteropeptidase compared to GD(4)K-NA.
Pack SizePriceAvailabilityQuantity
25 mg$29In Stock
50 mg$32In Stock
1 mL x 10 mM (in DMSO)$29In Stock
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Purity:98.38%
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COA HPLC HNMR LCMS

Product Introduction

Bioactivity
Description
7-Amino-4-methylcoumarin-3-acetic acid [7-Amino-4-methylcoumarin] is a more suitable substrate for enteropeptidase compared to GD(4)K-NA.
In vitro
In this study, we used shift in the emission spectrum of GD(4)K-conjugated 7-Amino-4-methylcoumarin (GD(4)K-AMC) as a fluorogenic method to measure enteropeptidase activity. The kinetic analysis revealed that enteropeptidase has a K(M) of 0.025 mM and a k(cat) of 65 sec(-1) for 7-Amino-4-methylcoumarin, whereas it has a K(M) of 0.5 to 0.6 mM and a k(cat) of 25 sec(-1) for GD(4)K-NA. The optimum pH of 7-Amino-4-methylcoumarin hydrolysis was pH 8.0.
Chemical Properties
Molecular Weight233.22
FormulaC12H11NO4
Cas No.106562-32-7
SmilesCc1c(CC(O)=O)c(=O)oc2cc(N)ccc12
Relative Density.1.391 g/cm3 at 20℃
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (235.83 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.2878 mL21.4390 mL42.8780 mL214.3898 mL
5 mM0.8576 mL4.2878 mL8.5756 mL42.8780 mL
10 mM0.4288 mL2.1439 mL4.2878 mL21.4390 mL
20 mM0.2144 mL1.0719 mL2.1439 mL10.7195 mL
50 mM0.0858 mL0.4288 mL0.8576 mL4.2878 mL
100 mM0.0429 mL0.2144 mL0.4288 mL2.1439 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

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