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Anti-Sphingosine Kinase 1/SPHK1 Antibody (6L121)
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Catalog No. TMAC-03836
Anti-Sphingosine Kinase 1/SPHK1 Antibody (6L121) is a Rabbit antibody targeting Sphingosine Kinase 1/SPHK1. Anti-Sphingosine Kinase 1/SPHK1 Antibody (6L121) can be used in WB,IHC,FCM.
Anti-Sphingosine Kinase 1/SPHK1 Antibody (6L121)
Anti-Sphingosine Kinase 1/SPHK1 Antibody (6L121)
😃Good
Catalog No. TMAC-03836
Anti-Sphingosine Kinase 1/SPHK1 Antibody (6L121) is a Rabbit antibody targeting Sphingosine Kinase 1/SPHK1. Anti-Sphingosine Kinase 1/SPHK1 Antibody (6L121) can be used in WB,IHC,FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $298 | 7-10 days | |
| 100 μL | $498 | 7-10 days |
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| Description | Anti-Sphingosine Kinase 1/SPHK1 Antibody (6L121) is a Rabbit antibody targeting Sphingosine Kinase 1/SPHK1. Anti-Sphingosine Kinase 1/SPHK1 Antibody (6L121) can be used in WB,IHC,FCM. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:500-1000; IHC: 1:50-200; FCM: 1:50 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | Sphingosine kinase (SphK or SphK1) is a key enzyme catalyzing the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP or S1P). Competitive inhibitors of SphK1 block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors. One potent inhibitor of SphK1 activity is DMS (N,N-dimethylsphingosine). SPP/SphK1 has been implicated as a signaling pathway that regulates diverse cellular functions, including cell growth, proliferation and survival. Specifically, SphK1 is involved in the signaling pathway(s) that protects human hepatocytes from the apoptotic action of TNFα. Furthermore, SPP/SphK1 may play an important role in neuronal survival by regulating activation of SAPKs and caspases. SphK1 is widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle; however, activation of SphK1 disengages cells from their liver-specific phenotype. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Antigen Species | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 51 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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