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Memantine hydrochloride

Name: Memantine hydrochloride
Brand: TargetMol
SKU: T1443
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1443Cas No. 41100-52-1

Alias Namenda, Memantine HCl, D-145 (hydrochloride)

Memantine hydrochloride (Memantine HCl) is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent.

Memantine hydrochloride

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Purity: 99.96%

Catalog No. T1443Alias Namenda, Memantine HCl, D-145 (hydrochloride)Cas No. 41100-52-1

Memantine hydrochloride (Memantine HCl) is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$42	In Stock	In Stock
500 mg	$50	In Stock	In Stock
1 g	$63	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.96%

Color:White

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COA HNMR LCMS

Product Introduction

Memantine hydrochloride AI Summary

Memantine hydrochloride demonstrates extensive bioactivity across a wide range of biological targets and disease models. It shows significant antiallodynic effects by increasing the paw withdrawal threshold in chronic sciatic nerve constriction injury rats from 2.8 g to 10.4 g after intraperitoneal administration of 60 mg/kg, indicating potential analgesic properties. The compound exhibits antiplasmodial activity against various Plasmodium falciparum strains, with IC50 values ranging from 1000.0 nM to 10000.0 nM over 72 hours, demonstrating potent antiparasitic effects. Additionally, Memantine hydrochloride has been identified as a modulator of multiple molecular targets, including inhibitors of APE1, AmpC Beta-Lactamase, and Neuropeptide S Receptor, among others. It also enhances the activity of the Vanilloid Receptor 1 and inhibits histone lysine methyltransferase G9a. The compound shows antiviral activity, such as inhibiting SARS-CoV-2-induced cytotoxicity in Caco-2 cells and exhibiting modest inhibition of SARS-CoV-2 3CL-Pro protease. However, its effectiveness against SARS-CoV-2 in VERO-6 cells was lower compared to a control antiviral agent. Memantine hydrochloride has antagonistic activity on rat brain GluN1/GluN2B and GluN1/GluN2A receptors, with IC50 values of 2099.0 nM and 1376.1 nM, respectively. It also displays antimicrobial activity against fungi like Candida albicans and bacteria such as Escherichia coli and Staphylococcus aureus MRSA, with varying degrees of inhibition. In cancer models, Memantine hydrochloride showed antiproliferative activity against human U-87 MG cells with an IC50 of 23590.0 nM and induced cell cycle arrest in human A 172 cells. These findings suggest that Memantine hydrochloride holds potential for multiple therapeutic applications, meriting further research and development..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Memantine hydrochloride (Memantine HCl) is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparkinson agent.
Targets&IC50	CYP2B6:0.51 nM(Ki), CYP2D6:94.9 μM(Ki)
Synonyms	Namenda, Memantine HCl, D-145 (hydrochloride)

Chemical Properties

Molecular Weight	215.76
Formula	C₁₂H₂₂ClN
Cas No.	41100-52-1
Smiles	Cl.[H][C@]12C[C@]3(C)C[C@](C)(C1)C[C@](N)(C2)C3
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (579.35 mM), Sonication is recommended.

H2O: 28 mg/mL (129.77 mM), Sonication is recommended.

Ethanol: 40 mg/mL (185.39 mM), Sonication is recommended.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6348 mL	23.1739 mL	46.3478 mL	231.7390 mL
5 mM	0.9270 mL	4.6348 mL	9.2696 mL	46.3478 mL
10 mM	0.4635 mL	2.3174 mL	4.6348 mL	23.1739 mL
20 mM	0.2317 mL	1.1587 mL	2.3174 mL	11.5869 mL
50 mM	0.0927 mL	0.4635 mL	0.9270 mL	4.6348 mL
100 mM	0.0463 mL	0.2317 mL	0.4635 mL	2.3174 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc