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Trevogrumab (Synonyms: REGN-1033, REGN1033)
Catalog No. T80951 Copy Product Info
Purity: 95%
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Trevogrumab (REGN-1033) is a fully human monoclonal antibody specifically designed to target and inhibit the activity of growth differentiation factor 8 (GDF8), which is also known as myostatin and functions as a negative regulator of muscle growth;Trevogrumab is currently under extensive research of sarcopenia, a complex condition characterized by progressive and generalized loss of skeletal muscle mass and function often associated with aging, wasting atrophy, various chronic diseases, and significant alterations in dietary and nutritional intake.
Trevogrumab
Copy Product Info🥰Excellent
Catalog No. T80951
Synonyms REGN-1033, REGN1033
Trevogrumab (REGN-1033) is a fully human monoclonal antibody specifically designed to target and inhibit the activity of growth differentiation factor 8 (GDF8), which is also known as myostatin and functions as a negative regulator of muscle growth;Trevogrumab is currently under extensive research of sarcopenia, a complex condition characterized by progressive and generalized loss of skeletal muscle mass and function often associated with aging, wasting atrophy, various chronic diseases, and significant alterations in dietary and nutritional intake.
Trevogrumab
Cas No. 1429201-24-0
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $415 | - | In Stock | |
| 5 mg | $1,230 | - | In Stock | |
| 10 mg | $1,650 | - | In Stock | |
| 25 mg | $2,450 | - | In Stock | |
| 50 mg | $3,290 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:97.6% (SDS-PAGE); 95.9% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Trevogrumab (REGN-1033) is a fully human monoclonal antibody specifically designed to target and inhibit the activity of growth differentiation factor 8 (GDF8), which is also known as myostatin and functions as a negative regulator of muscle growth;Trevogrumab is currently under extensive research of sarcopenia, a complex condition characterized by progressive and generalized loss of skeletal muscle mass and function often associated with aging, wasting atrophy, various chronic diseases, and significant alterations in dietary and nutritional intake. |
| In vitro | Human skeletal myoblasts were treated with Trevogrumab (40 nM, 30 minutes), and the target protein levels were detected by Western Blot. Results: Trevogrumab effectively inhibited myostatin-induced Smad2/3 activation, showing high affinity and specificity. [1] |
| In vivo | Trevogrumab (0.1-30 mg/kg, subcutaneously, twice a week for 4 weeks) treated mice resulted in a significant increase in gastrocnemius (GA) and tibialis anterior (TA) muscle weight (~20%) and an increase in myofiber area (~15%).[1] |
| Synonyms | REGN-1033, REGN1033 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | GDF8/Myostatin |
| Molecular Weight | 144.02 kDa |
| Cas No. | 1429201-24-0 |
| Isotype | Human IgG4 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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