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Trevogrumab
🥰Excellent
Catalog No. T80951Cas No. 1429201-24-0
Alias REGN-1033, REGN1033
Trevogrumab (REGN-1033) is a fully human monoclonal antibody specifically designed to target and inhibit the activity of growth differentiation factor 8 (GDF8), which is also known as myostatin and functions as a negative regulator of muscle growth;Trevogrumab is currently under extensive research of sarcopenia, a complex condition characterized by progressive and generalized loss of skeletal muscle mass and function often associated with aging, wasting atrophy, various chronic diseases, and significant alterations in dietary and nutritional intake.
Trevogrumab
Trevogrumab
🥰Excellent
Purity: 95%
Catalog No. T80951Alias REGN-1033, REGN1033Cas No. 1429201-24-0
Trevogrumab (REGN-1033) is a fully human monoclonal antibody specifically designed to target and inhibit the activity of growth differentiation factor 8 (GDF8), which is also known as myostatin and functions as a negative regulator of muscle growth;Trevogrumab is currently under extensive research of sarcopenia, a complex condition characterized by progressive and generalized loss of skeletal muscle mass and function often associated with aging, wasting atrophy, various chronic diseases, and significant alterations in dietary and nutritional intake.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $415 | In Stock | |
| 5 mg | $1,230 | In Stock | |
| 10 mg | $1,650 | In Stock | |
| 25 mg | $2,450 | In Stock | |
| 50 mg | $3,290 | In Stock |
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Concentration:6.86 mg/mL
Purity:95%
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Product Introduction
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Chemical Properties
| Description | Trevogrumab (REGN-1033) is a fully human monoclonal antibody specifically designed to target and inhibit the activity of growth differentiation factor 8 (GDF8), which is also known as myostatin and functions as a negative regulator of muscle growth;Trevogrumab is currently under extensive research of sarcopenia, a complex condition characterized by progressive and generalized loss of skeletal muscle mass and function often associated with aging, wasting atrophy, various chronic diseases, and significant alterations in dietary and nutritional intake. |
| In vitro | Human skeletal myoblasts were treated with Trevogrumab (40 nM, 30 minutes), and the target protein levels were detected by Western Blot. Results: Trevogrumab effectively inhibited myostatin-induced Smad2/3 activation, showing high affinity and specificity. [1] |
| In vivo | Trevogrumab (0.1-30 mg/kg, subcutaneously, twice a week for 4 weeks) treated mice resulted in a significant increase in gastrocnemius (GA) and tibialis anterior (TA) muscle weight (~20%) and an increase in myofiber area (~15%).[1] |
| Synonyms | REGN-1033, REGN1033 |
| Cas No. | 1429201-24-0 |
Storage & Solubility Information
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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