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Anti-Niemann Pick C1/NPC1 Antibody (1B891)

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Catalog No. TMAC-02848

Anti-Niemann Pick C1/NPC1 Antibody (1B891) is a Rabbit antibody targeting Niemann Pick C1/NPC1. Anti-Niemann Pick C1/NPC1 Antibody (1B891) can be used in WB,ICC,IF,IHC,FCM.

Anti-Niemann Pick C1/NPC1 Antibody (1B891)

Anti-Niemann Pick C1/NPC1 Antibody (1B891)

😃Good
Catalog No. TMAC-02848
Anti-Niemann Pick C1/NPC1 Antibody (1B891) is a Rabbit antibody targeting Niemann Pick C1/NPC1. Anti-Niemann Pick C1/NPC1 Antibody (1B891) can be used in WB,ICC,IF,IHC,FCM.
Pack SizePriceAvailabilityQuantity
50 μL$2987-10 days
100 μL$4967-10 days
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Product Introduction

Bioactivity
Description
Anti-Niemann Pick C1/NPC1 Antibody (1B891) is a Rabbit antibody targeting Niemann Pick C1/NPC1. Anti-Niemann Pick C1/NPC1 Antibody (1B891) can be used in WB,ICC,IF,IHC,FCM.
Ig Type
IgG
Reactivity
Human,Mouse,Rat
Application
Recommended Dose
WB: 1:500-1000; IHC: 1:50-200; ICC:IF: 1:50-200; FCM: 1:50-100
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundCells obtain cholesterol via two distinct pathways, endogenous synthesis in the endoplasmic reticulum and exogenous uptake through the low-density lipoprotein (LDL) receptor pathway. NPC1 is a protein that resides in late endosomes and lysosomes and is involved in the intracellular trafficking of cholesterol. The human NPC1 gene maps to chromosome 18q11.2 and produces proteins which undergo N-glycosylation and are expressed in brain and liver. NPC1 contains a cysteine-rich domain, which is critical for proper protein function, but is highly mutated. Mutations in NPC1 result in Niemann-Pick disease type C (NPC), an autosomal recessive disease characterized by the accumulation of unesterified cholesterol in the endosomal/lysosomal system. The accumulation of cholesterol results in progressive neurodegeneration and death. More than 90% of cases of NPC are due to mutations in NPC1 and patients with NPC display multiple neurological symptoms, such as hepatosplenomegaly, ataxia, dystonia and dementia.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein
Antigen Species
Recombinant Protein
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 142 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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