CCR2 Protein-VLP, Human, Recombinant (Flag)

Name: CCR2 Protein-VLP, Human, Recombinant (Flag)
Brand: TargetMol
SKU: TMPY-07138
Rating: 4.5 (1 reviews)

(Synonyms: PCLUD, MCP-1-R, FLJ78302, CMKBR2, CKR2B, CKR2A, CKR2, CD192, CCR2B, CCR2A, CCR-2, CC-CKR-2) Copy Product Info

Synonyms: PCLUD, MCP-1-R, FLJ78302, CMKBR2, CKR2B, CKR2A, CKR2, CD192, CCR2B, CCR2A, CCR-2, CC-CKR-2

Catalog No. TMPY-07138 Copy Product Info

CCR2 Protein-VLP, Human, Recombinant (Flag) is expressed in HEK293 Cells. The accession number is P41597-2.

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Pack Size	Price	USA Stock	Global Stock
10 µg	$460	7-10 days	7-10 days
20 µg	$773	7-10 days	7-10 days
50 µg	$1,180	7-10 days	7-10 days
100 µg	$1,870	7-10 days	7-10 days
200 µg	$2,800	7-10 days	7-10 days
500 µg	$6,630	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:The purity information is not available for VLPs proteins.

Appearance:Solution

Color:Transparent

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Immobilized CCR2 Protein-VLP, Human, Recombinant (Flag) (Cat#TMPY-07138) at 5 μg/mL (100 μL/well) can bind Plozalizumab-Derived Anti-CCR2 Antibody, Human IgG1, the EC50 is 5-25 ng/mL.
Description	CCR2 Protein-VLP, Human, Recombinant (Flag) is expressed in HEK293 Cells. The accession number is P41597-2.
Species	Human
Expression System	HEK293 Cells
Tag	N-Flag
Accession Number	P41597-2
Construction	A DNA sequence encoding the Human CCR2 (P41597-2) (Met1-Phe328,thermostabilizing mutations) was expressed with a flag tag at the N-terminus.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Supplied as sterile 50 mM Hepes, 150 mM NaCl, 10% Trehalose, Protease inhibitor, pH 7.2. Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Synonyms	PCLUD, MCP-1-R, FLJ78302, CMKBR2, CKR2B, CKR2A, CKR2, CD192, CCR2B, CCR2A, CCR-2, CC-CKR-2
Research Background	The C-C motif chemokine receptor-2 (CCR2) is a G protein-coupled receptor (GPCR), made up of a carboxy-terminus, extracellular amino terminus, and a hydrophobic transmembrane domain consisting of 7 amino acid segments that mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. CCR2 is expressed on monocytes, immature dendritic cells, and T-cell subpopulations, and mediates their migration towards endogenous CCL2. CCR2 is necessary for macrophage-dependent inflammatory responses and the development of atherosclerosis. In mice, CCR2 deficiency reduced macrophage content, increased adiponectin expression, ameliorated hepatic steatosis, and improved systemic glucose homeostasis and insulin sensitivity. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. Furthermore, CCR2 mRNA was highly expressed in prostate cancer (PCa) metastatic tissues compared with benign prostate tissues according to real-time RT-PCR3, suggesting that CCR2 may contribute to PCa development.

Chemical Properties

Molecular Weight

38.82 kDa (predicted)

Storage & Solubility Information

Shipping	Proteins are shipped with blue ice.
Storage	Samples are stable for up to twelve months from date of receipt at -70℃. Store it under sterile conditions at -70℃ or lower. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.