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ICR-191 dihydrochloride

Name: ICR-191 dihydrochloride
Brand: TargetMol
SKU: T217308
Rating: 4.5 (1 reviews)

Catalog No. T217308 Copy Product Info

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ICR-191 enhances the binding of Cisplatin to DNA and increases cell sensitivity to Cisplatin. It significantly elevates the expression of phosphorylated H2AX (γH2AX), particularly in cells undergoing DNA replication, and is applicable in leukemia research.

ICR-191 dihydrochloride

Copy Product Info

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Catalog No. T217308

ICR-191 dihydrochloride

Cas No. 17070-45-0

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description

In vitro

ICR-191 induces mutations such as G insertions in CHO-ICR cells over 16 hours, creating new GG sites and increasing cisplatin binding sites. The IC 50 value of cisplatin in these cells is reduced to 15.96 μM, compared to 25.42 μM in CHO wild-type (WT) cells. The fluorescence intensity of ICR-191 (8-12 μM) decreases with increasing CHL concentration. ICR-191 (8-10.1 μM) interacts with DNA through intercalation but has relatively low affinity. Additionally, ICR-191 (1.2 μM, 1 hour) induces phosphorylation of histone H2AX (γH2AX) in HL-60 cells, especially during the S phase.

Chemical Properties

Molecular Weight	451.21
Formula	C₁₉H₂₃Cl₄N₃O
Cas No.	17070-45-0
Smiles	ClC(C=CC1=C2NCCCNCCCl)=CC1=NC3=C2C=C(OC)C=C3.Cl.Cl

Storage & Solubility Information

Storage

Store at -20°C Shipping with blue ice/Shipping at ambient temperature.

Citations

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc