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Anti-infective agent 5

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Catalog No. T61158Cas No. 2738381-47-8

Anti-infective agent 5 (compound 74) is an orally active inhibitor of Trypanosoma cruzi with an IC50 value of 0.10 μM, demonstrating efficacy in reducing parasite burden in vivo and holding promising potential for infection research. [1]

Anti-infective agent 5

Anti-infective agent 5

😃Good
Catalog No. T61158Cas No. 2738381-47-8
Anti-infective agent 5 (compound 74) is an orally active inhibitor of Trypanosoma cruzi with an IC50 value of 0.10 μM, demonstrating efficacy in reducing parasite burden in vivo and holding promising potential for infection research. [1]
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,5206-8 weeks6-8 weeks
50 mg$1,9806-8 weeks6-8 weeks
100 mg$2,5006-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
Anti-infective agent 5 (compound 74) is an orally active inhibitor of Trypanosoma cruzi with an IC50 value of 0.10 μM, demonstrating efficacy in reducing parasite burden in vivo and holding promising potential for infection research. [1]
In vitro
The anti-infective agent 5, administered at concentrations ranging from 0.1 nM to 100 μM for 48 hours, exhibits antitrypanosomal effects against T. cruzi amastigotes within 3T3 cells, achieving an IC50 of 0.10 μM [1]. Furthermore, in cytotoxicity assays conducted on the 3T3 cell line under the same conditions, the compound demonstrated a CC50 value of over 37 μM, indicating its activity and potential selectivity towards the pathogen while maintaining a lower toxicity profile towards the host cells [1].
In vivo
The anti-infective agent 5, administered orally at a dosage of 50 mg/kg twice daily for five days, significantly reduced the parasite burden in a BALB/c mouse model infected with bioluminescent T. cruzi CL Brener parasites. This treatment resulted in a greater than 98-99% decrease in parasite levels without causing notable adverse effects in the mice [1].
Chemical Properties
Molecular Weight347.33
FormulaC18H13N5O3
Cas No.2738381-47-8
SmilesO=C1C=2N(C=C(N(=O)=O)N2)C=CN1CC3=CC=C(C=C3)C=4C=CC=NC4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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