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GSK-4381562
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Catalog No. T9901A-1473 Copy Product Info
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GSK-4381562 represents a highly specialized fully human monoclonal antibody specifically engineered to target the human PVR-related immunoglobulin domain-containing protein with exceptional binding affinity and selectivity, effectively facilitating the measurable blockade of the inhibitory interaction between PVRIG and its primary ligand PVRL2 across various preclinical experimental models to evaluate the restoration of anti-tumor cytotoxic responses during strictly monitored laboratory observation periods.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $278 | Inquiry | Inquiry | |
| 5 mg | $986 | Inquiry | Inquiry | |
| 10 mg | $1,570 | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | GSK-4381562 represents a highly specialized fully human monoclonal antibody specifically engineered to target the human PVR-related immunoglobulin domain-containing protein with exceptional binding affinity and selectivity, effectively facilitating the measurable blockade of the inhibitory interaction between PVRIG and its primary ligand PVRL2 across various preclinical experimental models to evaluate the restoration of anti-tumor cytotoxic responses during strictly monitored laboratory observation periods. |
| In vitro | In T cell activation assays using human cancer cells, GSK-4381562 (Anti-PVRIG) blocked the PVRIG/PVRL2 interaction, enhancing CD8+ T cell proliferation and IFN-gamma secretion [1]. |
| In vivo | In humanized mouse tumor models, systemic administration of GSK-4381562 (Anti-PVRIG) significantly suppressed tumor growth and increased intratumoral immune cell infiltration [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | PVRIG |
| Isotype | IgG1 |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: GSK-4381562 chemical structure | GSK-4381562 in vivo | GSK-4381562 in vitro
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