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PS10

Name: PS10
Brand: TargetMol
SKU: T12566
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12566Cas No. 1564265-82-2

Alias PS 10

PS10 is a broad-spectrum PDK inhibitor that inhibits PDK2, PDK4, PDK1, and PDK3. It significantly increases pyruvate dehydrogenase complex activity, and is used in research on obesity and type 2 diabetes.

PS10

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Purity: 99.01%

Catalog No. T12566Alias PS 10Cas No. 1564265-82-2

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$69	-	In Stock
10 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$149	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.01%

Appearance:Solid

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COA

Product Introduction

Bioactivity

Description	PS10 is a broad-spectrum PDK inhibitor that inhibits PDK2, PDK4, PDK1, and PDK3. It significantly increases pyruvate dehydrogenase complex activity, and is used in research on obesity and type 2 diabetes.
Targets&IC50	PDK3:2.1 μM, PDK4:0.76 μM, PDK1:21.3 μM, PDK2:0.8 μM
In vitro	PS10 is a pan-PDK inhibitor with IC50 of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM for PDK2, PDK4, PDK1 and PDK3, respectively. The Kd value combined with PDK2 is 239 nM. [1]
In vivo	PS10 (70 mg/kg/ day for 3 days) stimulated PDC activity in DIO mice, increased glucose tolerance and reduced hepatic steatosis in DIO mice. [1] PS10 (70 mg/kg/ day, 4 weeks, intraperitoneal injection), mice showed significant improvements in glucose, insulin, and pyruvate tolerance, lower plasma insulin levels, and increased liver insulin signaling. [2]
Synonyms	PS 10

Chemical Properties

Molecular Weight	323.32
Formula	C₁₄H₁₃NO₆S
Cas No.	1564265-82-2
Smiles	O=S(=O)(C1=CC=C(O)C=C1O)N2CC=3C=C(O)C=C(O)C3C2
Relative Density.	1.696 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (154.65 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (15.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0929 mL	15.4646 mL	30.9291 mL	154.6456 mL
5 mM	0.6186 mL	3.0929 mL	6.1858 mL	30.9291 mL
10 mM	0.3093 mL	1.5465 mL	3.0929 mL	15.4646 mL
20 mM	0.1546 mL	0.7732 mL	1.5465 mL	7.7323 mL
50 mM	0.0619 mL	0.3093 mL	0.6186 mL	3.0929 mL
100 mM	0.0309 mL	0.1546 mL	0.3093 mL	1.5465 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc