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PS10

Name: PS10
Brand: TargetMol
SKU: T12566
Rating: 4.5 (1 reviews)

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Catalog No. T12566Cas No. 1564265-82-2

Alias PS 10

PS10 is a broad-spectrum PDK inhibitor that inhibits PDK2, PDK4, PDK1, and PDK3. It significantly increases pyruvate dehydrogenase complex activity, and is used in research on obesity and type 2 diabetes.

PS10

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Purity: 99.01%

Catalog No. T12566Alias PS 10Cas No. 1564265-82-2

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Purity:99.01%

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Product Introduction

Bioactivity

Description	PS10 is a broad-spectrum PDK inhibitor that inhibits PDK2, PDK4, PDK1, and PDK3. It significantly increases pyruvate dehydrogenase complex activity, and is used in research on obesity and type 2 diabetes.
Targets&IC50	PDK4:0.76 μM, PDK1:21.3 μM, PDK3:2.1 μM, PDK2:0.8 μM
In vitro	PS10 is a pan-PDK inhibitor with IC50 of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM for PDK2, PDK4, PDK1 and PDK3, respectively. The Kd value combined with PDK2 is 239 nM. [1]
In vivo	PS10 (70 mg/kg/ day for 3 days) stimulated PDC activity in DIO mice, increased glucose tolerance and reduced hepatic steatosis in DIO mice. [1] PS10 (70 mg/kg/ day, 4 weeks, intraperitoneal injection), mice showed significant improvements in glucose, insulin, and pyruvate tolerance, lower plasma insulin levels, and increased liver insulin signaling. [2]
Synonyms	PS 10

Chemical Properties

Molecular Weight	323.32
Formula	C₁₄H₁₃NO₆S
Cas No.	1564265-82-2
Smiles	O=S(=O)(C1=CC=C(O)C=C1O)N2CC=3C=C(O)C=C(O)C3C2
Relative Density.	1.696 g/cm3 (Predicted)
Color	Brown
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (154.65 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (15.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0929 mL	15.4646 mL	30.9291 mL	154.6456 mL
5 mM	0.6186 mL	3.0929 mL	6.1858 mL	30.9291 mL
10 mM	0.3093 mL	1.5465 mL	3.0929 mL	15.4646 mL
20 mM	0.1546 mL	0.7732 mL	1.5465 mL	7.7323 mL
50 mM	0.0619 mL	0.3093 mL	0.6186 mL	3.0929 mL
100 mM	0.0309 mL	0.1546 mL	0.3093 mL	1.5465 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc