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SK1-IN-1

Name: SK1-IN-1
Brand: TargetMol
SKU: T12927
Price: 199 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12927Cas No. 1218816-71-7

SK1-IN-1 is an orally available and potent sphingosine kinase 1 (SPHK1) inhibitor (IC50: 58 nM), with potential anticancer activity, and can be used to study cancer and neurodegenerative diseases.

SK1-IN-1

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Purity: 98.72%

Catalog No. T12927Cas No. 1218816-71-7

SK1-IN-1 is an orally available and potent sphingosine kinase 1 (SPHK1) inhibitor (IC50: 58 nM), with potential anticancer activity, and can be used to study cancer and neurodegenerative diseases.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$199	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.72%

Appearance:Solid

Color:Yellow

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COA LCMS

Product Introduction

Bioactivity

Description	SK1-IN-1 is an orally available and potent sphingosine kinase 1 (SPHK1) inhibitor (IC50: 58 nM), with potential anticancer activity, and can be used to study cancer and neurodegenerative diseases.
Targets&IC50	SPHK1:58 nM
In vitro	SK1-IN-1 can inhibit sphingosine kinase 1 (SPHK1) with an IC50 value of 58 nM.
In vivo	b>METHODS: SK1-IN-1 (1 mg/kg, intravenous injection; 3 mg/kg, oral administration) was studied for its pharmacokinetic properties in rats. RESULTS: SK1-IN-1 showed moderate oral bioavailability and acceptable blood circulation half-life. The bioavailability of SK1-IN-1 in rats after oral administration was 17.6%, and the half-lives in rat blood circulation after intravenous injection and oral administration were 4.30 hours and 7.5 hours, respectively. [1]

Chemical Properties

Molecular Weight	398.5
Formula	C₂₂H₃₀N₄O₃
Cas No.	1218816-71-7
Smiles	C(CC1CCCC1)C2=NC(=NO2)C3=CC=C([C@@H](NC(=O)[C@@H]4[C@@H](O)CCN4)C)C=C3
Relative Density.	1.200 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (200.75 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.28 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5094 mL	12.5471 mL	25.0941 mL	125.4705 mL
5 mM	0.5019 mL	2.5094 mL	5.0188 mL	25.0941 mL
10 mM	0.2509 mL	1.2547 mL	2.5094 mL	12.5471 mL
20 mM	0.1255 mL	0.6274 mL	1.2547 mL	6.2735 mL
50 mM	0.0502 mL	0.2509 mL	0.5019 mL	2.5094 mL
100 mM	0.0251 mL	0.1255 mL	0.2509 mL	1.2547 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc