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Synonyms: UNQ778/PRO1572, SFTPJ, SFTA5, Claudin 18.2
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 100 μL | $383 | 7-10 days | 7-10 days |
| Description | Anti-Claudin18.2 Antibody (3E88) is a Mouse antibody targeting Claudin18.2. Anti-Claudin18.2 Antibody (3E88) can be used in ELISA,IHC-P,WB. |
| Synonyms | UNQ778/PRO1572, SFTPJ, SFTA5, Claudin 18.2 |
| Ig Type | Mouse IgG2a |
| Clone | 3E88 |
| Reactivity | Human |
| Specificity | Human Claudin18.2 Has cross-reactivity in WB and ELISA with Human Claudin18.2-VLP (Full Length) Protein Has cross-reactivity in ELISA with Human CLDN18.2-Nanodisc (Full Length) Protein |
| Application | |
| Recommended Dose | WB: 1:500-1:2000; ELISA: 1:1000-1:2000; IHC-P: 1:500-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with Human Claudin18.2 mRNA. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Claudins family member Claudin18 (CLDN18) is a four-pass transmembrane protein with two extracellular loops and cytoplasmic N- and C-tails found in tight junctions. CLDN18 modulates paracellular permeability, polarity, and signaling. CLDN18 deficiency has been associated with atrophic gastritis, spasmolytic polypeptide-expressing metaplasia (SPEM), and asthma. Lung-specific CLDN18.1 modulates alveolar epithelial type II (AT2) cell proliferation and organ size. Restoration of CLDN18.1 expression in human lung cancer cells has been shown to suppress proliferation, inhibiting the IGF-1R/AKT axes. Not expressed in other healthy tissues, gastric mucosa-specific isoform CLDN18.2 expression manifests in primary gastric cancers. CLDN18.2 at the surface of epithelial tumor cells is a target in antibody and CAR-therapies currently in development. |
| Conjucates | Unconjugated |
| Immunogen | Human Claudin18.2 mRNA |
| Antigen Species | Human |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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