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Anti-Claudin18.2 Antibody (3E88)
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Catalog No. TMAY-02847
Alias UNQ778/PRO1572, SFTPJ, SFTA5, Claudin 18.2
Anti-Claudin18.2 Antibody (3E88) is a Mouse antibody targeting Claudin18.2. Anti-Claudin18.2 Antibody (3E88) can be used in WB,ELISA,IHC-P.
Anti-Claudin18.2 Antibody (3E88)
Anti-Claudin18.2 Antibody (3E88)
😃Good
Catalog No. TMAY-02847Alias UNQ778/PRO1572, SFTPJ, SFTA5, Claudin 18.2
Anti-Claudin18.2 Antibody (3E88) is a Mouse antibody targeting Claudin18.2. Anti-Claudin18.2 Antibody (3E88) can be used in WB,ELISA,IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Claudin18.2 Antibody (3E88) is a Mouse antibody targeting Claudin18.2. Anti-Claudin18.2 Antibody (3E88) can be used in WB,ELISA,IHC-P. |
| Alias | UNQ778/PRO1572, SFTPJ, SFTA5, Claudin 18.2 |
| Ig Type | Mouse IgG2a |
| Clone | 3E88 |
| Reactivity | Human |
| Verified Activity | 1. Anti-Claudin18.2 mouse monoclonal antibody at 1:1000 dilution. -Lane A: Human Claudin18.2-VLP (Full Length) Protein 500ng -Lane B: Virus-Like Particle (VLP) isotype control Protein 500ng -Secondary -Goat Anti-Mouse IgG (H+L)/HRP at 1/10000 dilution. -Developed using the ECL technique. -Performed under reducing conditions. 2. Immunochemical staining of human Claudin18 in human stomach with mouse monoclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections. 3. Immunochemical staining of human Claudin18 in human lung with mouse monoclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections. 4. Immunochemical staining of human Claudin18 in human gastric cancer with mouse monoclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections. |
| Application | WB,ELISA,IHC-P |
| Recommended Dose | WB: 1:500-1:2000; ELISA: 1:1000-1:2000; IHC-P: 1:500-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with Human Claudin18.2 mRNA. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Claudins family member Claudin18 (CLDN18) is a four-pass transmembrane protein with two extracellular loops and cytoplasmic N- and C-tails found in tight junctions. CLDN18 modulates paracellular permeability, polarity, and signaling. CLDN18 deficiency has been associated with atrophic gastritis, spasmolytic polypeptide-expressing metaplasia (SPEM), and asthma. Lung-specific CLDN18.1 modulates alveolar epithelial type II (AT2) cell proliferation and organ size. Restoration of CLDN18.1 expression in human lung cancer cells has been shown to suppress proliferation, inhibiting the IGF-1R/AKT axes. Not expressed in other healthy tissues, gastric mucosa-specific isoform CLDN18.2 expression manifests in primary gastric cancers. CLDN18.2 at the surface of epithelial tumor cells is a target in antibody and CAR-therapies currently in development. |
| Conjucates | Unconjugated |
| Immunogen | Human Claudin18.2 mRNA |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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