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Chlorphenesin Carbamate (Synonyms: U 19646, Rinlaxer, Maolate, Kolpicortin-sine)

Name: Chlorphenesin Carbamate
Brand: TargetMol
SKU: T21376
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T21376 Copy Product Info

Purity: 99.96%

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Chlorphenesin Carbamate is a skeletal muscle relaxant acting on the central nervous system, which can be used in research related to skeletal muscle injury and inflammation-associated pain. Its mechanism of action mainly involves the selective blockade of spinal polysynaptic transmission pathways and certain analgesic activity.

Chlorphenesin Carbamate

Copy Product Info

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Catalog No. T21376

Synonyms U 19646, Rinlaxer, Maolate, Kolpicortin-sine

Cas No. 886-74-8

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Pack Size	Price	USA Stock	Global Stock
5 mg	$30	-	In Stock
10 mg	$42	-	In Stock
25 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$46	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.96%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Chlorphenesin Carbamate is a skeletal muscle relaxant acting on the central nervous system, which can be used in research related to skeletal muscle injury and inflammation-associated pain. Its mechanism of action mainly involves the selective blockade of spinal polysynaptic transmission pathways and certain analgesic activity.
In vivo	Chlorphenesin Carbamate (CPC) inhibits monosynaptic reflex (MSR) and polysynaptic reflex (PSR) at an intravenous dose of 50 mg/kg. The polysynaptic reflex is more sensitive to CPC inhibition than the monosynaptic reflex.In addition, CPC exerts a marked inhibitory effect on spinal neurons and induces hyperpolarization of both ventral and dorsal roots in the isolated frog spinal cord [2]. Chlorphenesin Carbamate (CPC) exhibits antinociceptive effects in a rat model of adjuvant-induced arthritis.Behavioral studies show that CPC produces dose-dependent antinociceptive effects when administered orally at doses of 100–400 mg/kg.Electrophysiological studies demonstrate that intravenous administration of CPC at 25–50 mg/kg inhibits evoked responses of nociceptive neurons in the ventrobasal thalamus (VB). At an intravenous dose of 50 mg/kg, CPC also suppresses spontaneous firing of nociceptive neurons in the VB region [3].
Synonyms	U 19646, Rinlaxer, Maolate, Kolpicortin-sine

Chemical Properties

Molecular Weight	245.66
Formula	C₁₀H₁₂ClNO₄
Cas No.	886-74-8
Smiles	O=C(OCC(O)COC1=CC=C(Cl)C=C1)N
Relative Density.	1.365g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (407.07 mM), Sonication is recommended.

H2O: Insoluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0707 mL	20.3533 mL	40.7067 mL	203.5333 mL
5 mM	0.8141 mL	4.0707 mL	8.1413 mL	40.7067 mL
10 mM	0.4071 mL	2.0353 mL	4.0707 mL	20.3533 mL
20 mM	0.2035 mL	1.0177 mL	2.0353 mL	10.1767 mL
50 mM	0.0814 mL	0.4071 mL	0.8141 mL	4.0707 mL
100 mM	0.0407 mL	0.2035 mL	0.4071 mL	2.0353 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc