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I3MT-3

Name: I3MT-3
Brand: TargetMol
SKU: T8851
Price: 70 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8851Cas No. 459420-09-8

Alias HMPSNE

I3MT-3 (HMPSNE) (HMPSNE) is a potent, selective and cell membrane permeability inhibitor of 3-mercaptopyruvate sulfur transferase (3MST), which targets the persulfated cysteine residues located at the active site of 3MST.

I3MT-3

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Purity: 99.76%

Catalog No. T8851Alias HMPSNECas No. 459420-09-8

Pack Size	Price	Availability
1 mg	$70	In Stock
5 mg	$172	In Stock
10 mg	$272	In Stock
25 mg	$455	In Stock
50 mg	$645	In Stock
100 mg	$892	In Stock
1 mL x 10 mM (in DMSO)	$185	In Stock

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Purity:99.76%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	I3MT-3 (HMPSNE) (HMPSNE) is a potent, selective and cell membrane permeability inhibitor of 3-mercaptopyruvate sulfur transferase (3MST), which targets the persulfated cysteine residues located at the active site of 3MST.
Targets&IC50	Hippo pathway:2.7 μM
In vitro	I3MT-3 shows a dose-dependent inhibition of 3-MST activity from CT26 homogenates, which contain the murine form of the enzyme. The IC50 of HMPSNE for murine 3-MST is calculated as 2.3 μM with a cozncentration-dependent decrease of AzMC fluorescence[1].I3MT-3 (0-300 μM; 48 hours) inhibits CT26 cells proliferate with increasing concentrations of I3MT-3. Confluence of cells treated with HMPSNE is recorded each hour for 48 h by the IncuCyte method[2].
Synonyms	HMPSNE

Chemical Properties

Molecular Weight	310.37
Formula	C₁₇H₁₄N₂O₂S
Cas No.	459420-09-8
Smiles	Cc1cc(=O)[nH]c(SCC(=O)c2cccc3ccccc23)n1
Relative Density.	1.30 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (386.64 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2220 mL	16.1098 mL	32.2196 mL	161.0980 mL
5 mM	0.6444 mL	3.2220 mL	6.4439 mL	32.2196 mL
10 mM	0.3222 mL	1.6110 mL	3.2220 mL	16.1098 mL
20 mM	0.1611 mL	0.8055 mL	1.6110 mL	8.0549 mL
50 mM	0.0644 mL	0.3222 mL	0.6444 mL	3.2220 mL
100 mM	0.0322 mL	0.1611 mL	0.3222 mL	1.6110 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc