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CAY10505

Name: CAY10505
Brand: TargetMol
SKU: T6433
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6433Cas No. 1218777-13-9

CAY10505, a form of dehydroxyl of AS-252424, is a PI3Kγ inhibitor (IC50: 33 nM).

CAY10505

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Purity: 99.74%

Catalog No. T6433Cas No. 1218777-13-9

CAY10505, a form of dehydroxyl of AS-252424, is a PI3Kγ inhibitor (IC50: 33 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$51	In Stock	In Stock
50 mg	$93	In Stock	In Stock
100 mg	$155	-	In Stock
200 mg	$228	-	In Stock
500 mg	$389	-	In Stock
1 mL x 10 mM (in DMSO)	$34	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.74%

Appearance:Solid

Resource Download

COA LCMS HNMR

Product Introduction

CAY10505 AI Summary

CAY10505 exhibits inhibition of IGF1R with an IC50 of 400.0 nM and displays notable antiproliferative activity against human MCF7 cells with an IC50 of 36900.0 nM. It shows no significant inhibition of IR, with an IC50 greater than 100000.0 nM. Additionally, CAY10505 demonstrates antiviral activity against SARS-CoV-2 by reducing cytotoxicity in Caco-2 cells at a concentration of 10 µM, resulting in a 3.59% inhibition level after 48 hours according to high content imaging analysis, and also shows 0.59% inhibition in VERO-6 cells under the same conditions. Although its SARS-CoV-2 3CL-Pro protease inhibition activity was noted at 20 µM, the inhibition was minimal (-7.565%). Furthermore, CAY10505 inhibits human HDAC6 activity with 60.27% inhibition observed in an enzymatic assay using a commercial peptide substrate and 31.75% inhibition with a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	CAY10505, a form of dehydroxyl of AS-252424, is a PI3Kγ inhibitor (IC50: 33 nM).
Targets&IC50	PI3Kγ:33 nM

Chemical Properties

Molecular Weight	289.28
Formula	C₁₄H₈FNO₃S
Cas No.	1218777-13-9
Smiles	Fc1ccc(cc1)-c1ccc(C=C2SC(=O)NC2=O)o1
Relative Density.	1.466 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 8 mg/mL (27.65 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4569 mL	17.2843 mL	34.5686 mL	172.8429 mL
5 mM	0.6914 mL	3.4569 mL	6.9137 mL	34.5686 mL
10 mM	0.3457 mL	1.7284 mL	3.4569 mL	17.2843 mL
20 mM	0.1728 mL	0.8642 mL	1.7284 mL	8.6421 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc