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Anti-Phospho-CHEK2 (Ser516) Polyclonal Antibody

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Catalog No. TMAC-00849

Anti-Phospho-CHEK2 (Ser516) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CHEK2 (Ser516). Anti-Phospho-CHEK2 (Ser516) Polyclonal Antibody can be used in WB.

Anti-Phospho-CHEK2 (Ser516) Polyclonal Antibody

Anti-Phospho-CHEK2 (Ser516) Polyclonal Antibody

😃Good
Catalog No. TMAC-00849
Anti-Phospho-CHEK2 (Ser516) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CHEK2 (Ser516). Anti-Phospho-CHEK2 (Ser516) Polyclonal Antibody can be used in WB.
Pack SizePriceAvailabilityQuantity
50 μL$2177-10 days
100 μL$3167-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-CHEK2 (Ser516) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CHEK2 (Ser516). Anti-Phospho-CHEK2 (Ser516) Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human
Application
Antibody Type
Polyclonal
Host SpeciesRabbit
ConstructionPolyclonal Antibody
PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
AppearanceLiquid
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Research BackgroundIn response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by Chk2 gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Three transcript variants encoding different isoforms have been found for this gene.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
Peptide sequence around phosphorylation site of serine 516 (Q-P-S(p)-T-S) derived from Human Chk2
Antigen Species
human
Uniprot ID
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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