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GDC-0276

Name: GDC-0276
Brand: TargetMol
SKU: T11377
Price: 132 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11377Cas No. 1494581-70-2

Alias RG-7893, RG7893, GDC0276

GDC-0276 is an orally active, selective, and potent NaV1.7 inhibitor that can be used for the study of pain-related diseases.

GDC-0276

🥰Excellent

Purity: 99.77%

Catalog No. T11377Alias RG-7893, RG7893, GDC0276Cas No. 1494581-70-2

GDC-0276 is an orally active, selective, and potent NaV1.7 inhibitor that can be used for the study of pain-related diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$132	In Stock	In Stock
5 mg	$328	In Stock	In Stock
10 mg	$562	-	In Stock
1 mL x 10 mM (in DMSO)	$336	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.77%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	GDC-0276 is an orally active, selective, and potent NaV1.7 inhibitor that can be used for the study of pain-related diseases.
Targets&IC50	NaV1.7 Electrophysiology:0.4 nM
In vitro	GDC-0276 is a potent, selective, reversible, orally active NaV1.7 inhibitor with an IC50 of 0.4 nM and a Ki of 1.1 nM. [1]
In vivo	In a mouse model of inherited erythromelalgia (IEM), GDC-0276 treatment showed a concentration-dependent reduction in nociceptive events with an EC50 of 1.7 μM. [1]
Synonyms	RG-7893, RG7893, GDC0276

Chemical Properties

Molecular Weight	462.58
Formula	C₂₄H₃₁FN₂O₄S
Cas No.	1494581-70-2
Smiles	O=C(NS(=O)(=O)N1CCC1)C=2C=C(C(OCC34CC5CC(CC(C5)C3)C4)=CC2F)C6CC6
Relative Density.	1.39 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (216.18 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 5 mg/mL (10.81 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1618 mL	10.8089 mL	21.6179 mL	108.0894 mL
5 mM	0.4324 mL	2.1618 mL	4.3236 mL	21.6179 mL
10 mM	0.2162 mL	1.0809 mL	2.1618 mL	10.8089 mL
20 mM	0.1081 mL	0.5404 mL	1.0809 mL	5.4045 mL
50 mM	0.0432 mL	0.2162 mL	0.4324 mL	2.1618 mL
100 mM	0.0216 mL	0.1081 mL	0.2162 mL	1.0809 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc